N-(1-Ethoxy-ethyl)-N-methyl-formamide | 19853-34-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(1-Ethoxy-ethyl)-N-methyl-formamide
• 英文别名: N-(1-ethoxyethyl)-N-methylformamide
• CAS: 19853-34-0
• 化学式: C₆H₁₃NO₂
• 分子量: 131.175
• InChiKey: MPJQFBZATVUSKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SYNTHESIS OF 1-HYDROXYETHYL FORMAMIDES AND N-VINYL FORMAMIDES<br/>[FR] SYNTHÈSE DE 1-HYDROXYÉTHYLFORMAMIDES ET DE N-VINYLFORMAMIDES
  申请人：TAMINCO BVBA

  公开号：WO2018041615A1

  公开（公告）日：2018-03-08

  Processes and systems for producing N-vinyl carboxylic acid amides are provided herein. According to some aspects of the present invention, a process for producing an N-vinyl carboxylic acid amide is described that eliminates interim solids handling steps during formation of the intermediate compounds, thereby increasing efficiency and reducing cost. The processes and system described herein may be used for the synthesis of N-vinylformamide and its intermediates, including 1-hydroxyethylformamide and 1- alkoxyethylformamide, or for the synthesis of N-methyl,N-vinylformamide and its intermediates, including N-methyl,1-hydroxyethylformamide and N- methyl,1alkoxyethylformamide.

  本文提供了用于生产N-乙烯羧酸酰胺的工艺和系统。根据本发明的某些方面，描述了一种生产N-乙烯羧酸酰胺的工艺，该工艺在形成中间化合物时消除了中间固体处理步骤，从而提高了效率并降低成本。本文描述的工艺和系统可用于合成N-乙烯甲酰胺及其中间体，包括1-羟基乙酰甲酰胺和1-烷氧基乙酰甲酰胺，或用于合成N-甲基，N-乙烯甲酰胺及其中间体，包括N-甲基，1-羟基乙酰甲酰胺和N-甲基，1-烷氧基乙酰甲酰胺。
• Process for producing tricyclic ketone
  申请人：Nishiyama Hiroyuki

  公开号：US20090023927A1

  公开（公告）日：2009-01-22

  In order to efficiently supply CPT, which is a starting compound of irinotecan hydrochloride and a variety of camptothecin derivatives, by a practical total synthesis, the invention provides a means of efficiently preparing a tricyclic ketone that corresponds to a CDE ring moiety of a camptothecin (CPT) skeleton.

  为了通过实际的全合成高效地供应伊立替康盐酸盐的起始化合物CPT和各种喜树碱衍生物，本发明提供了一种有效制备对应于喜树碱（CPT）骨架中的CDE环部分的三环酮的方法。
• PROCESS FOR PRODUCING TRICYCLIC KETONE
  申请人：Nishiyama Hiroyuki

  公开号：US20120041204A1

  公开（公告）日：2012-02-16

  In order to efficiently supply CPT, which is a starting compound of irinotecan hydrochloride and a variety of camptothecin derivatives, by a practical total synthesis, the invention provides a means of efficiently preparing a tricyclic ketone that corresponds to a CDE ring moiety of a camptothecin (CPT) skeleton.

  为了通过实用的全合成方法高效地合成伊立替康盐酸盐和多种喜树碱衍生物的起始化合物CPT，本发明提供了一种有效制备与喜树碱（CPT）骨架的CDE环部分相应的三环酮的方法。
• Synthesis of N-vinyl carboxylic acid amides
  申请人：Taminco BVBA

  公开号：US10696622B2

  公开（公告）日：2020-06-30

  Processes and systems for producing N-vinyl carboxylic acid amides are provided herein. According to some aspects of the present invention, a process for producing an N-vinyl carboxylic acid amide is described that eliminates interim solids handling steps during formation of the intermediate compounds, thereby increasing efficiency and reducing cost. The processes and system described herein may be used for the synthesis of N-vinylformamide and its intermediates, including 1-hydroxyethylformamide and 1-alkoxyethylformamide, or for the synthesis of N-methyl,N-vinylformamide and its intermediates, including N-methyl,1-hydroxyethylformamide and N-methyl,1alkoxyethylformamide.

  本文提供了生产 N-乙烯基羧酸酰胺的工艺和系统。根据本发明的某些方面，描述了一种生产 N-乙烯基羧酸酰胺的工艺，该工艺省去了中间化合物形成过程中的固体处理步骤，从而提高了效率并降低了成本。本文所述的工艺和系统可用于合成 N-乙烯基甲酰胺及其中间体，包括 1-羟乙基甲酰胺和 1-烷氧基乙基甲酰胺，或用于合成 N-甲基、N-乙烯基甲酰胺及其中间体，包括 N-甲基、1-羟乙基甲酰胺和 N-甲基、1-烷氧基乙基甲酰胺。
• SYNTHESIS OF 1-HYDROXYETHYL FORMAMIDES AND N-VINYL FORMAMIDES
  申请人：Taminco BVBA

  公开号：EP3504184A1

  公开（公告）日：2019-07-03