6-Chlor-7-methyl-1,2,4-benzothiadiazin-1,1-dioxid | 3322-72-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 6-Chlor-7-methyl-1,2,4-benzothiadiazin-1,1-dioxid
• 英文别名: 6-Chlor-7-methyl-1,2,4-benzothiodiazin-1,1-dioxyd；6-chloro-7-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide；6-chloro-7-methyl-4H-1lambda6,2,4-benzothiadiazine 1,1-dioxide；6-chloro-7-methyl-4H-1λ6,2,4-benzothiadiazine 1,1-dioxide
• CAS: 3322-72-3
• 化学式: C₈H₇ClN₂O₂S
• 分子量: 230.675
• InChiKey: LHSVXUHURPRLFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• CHLOROTHIAZIDE, CHLOROTHIAZIDE SALTS AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Sathe Dhananjay Govind

  公开号：US20110263579A1

  公开（公告）日：2011-10-27

  The present invention relates to an improved process for the preparation of Chlorothiazide and pharmaceutically acceptable salts thereof. The present invention relates to novel polymorphs of Chlorothiazide and Chlorothiazide salts, in particular Chlorothiazide sodium. The present invention further relates to pharmaceutical compositions comprising Chlorothiazide and Chlorothiazide salts, in particular Chlorothiazide sodium and process for preparation thereof.

  本发明涉及一种改进的氯噻嗪及其药用可接受盐的制备方法。本发明涉及氯噻嗪及氯噻嗪盐的新型多晶形态，特别是氯噻嗪钠。本发明还涉及包含氯噻嗪及氯噻嗪盐，特别是氯噻嗪钠的药物组合物，以及其制备方法。
• COMPOSITIONS AND METHODS COMPRISING A THIAZIDE DIURETIC AND A MINERALOCORTICOID INHIBITOR
  申请人：Solomon Lawrence

  公开号：US20070287690A1

  公开（公告）日：2007-12-13

  The invention relates to low dose combinations of a thiazide diuretic and a mineralocorticoid inhibitor and methods for the treatment of hypertension and related disorders. Methods and compositions for administering a thiazide diuretic, such as chlorthalidone, and an mineralocorticoid inhibitor such as spironolactone or eplerenone in a dose range of between 3 mg and 12 mg or eplerenone in a dose range of between 3 mg and 25 mg each,