1-[4-(4-amino-5-oxo-5H-pyrido[2,3-d]pyrimidin-8-yl)phenyl]-3-[4-chloro-2-(2-dimethylaminoethoxy)phenyl]urea | 852221-96-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-[4-(4-amino-5-oxo-5H-pyrido[2,3-d]pyrimidin-8-yl)phenyl]-3-[4-chloro-2-(2-dimethylaminoethoxy)phenyl]urea
• 英文别名: 1-[4-(4-Amino-5-oxopyrido[2,3-d]pyrimidin-8-yl)phenyl]-3-[4-chloro-2-[2-(dimethylamino)ethoxy]phenyl]urea
• CAS: 852221-96-6
• 化学式: C₂₄H₂₄ClN₇O₃
• 分子量: 493.953
• InChiKey: FRFXBYMEIKEBQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Pyridopyrimidinones
  申请人：Hoelzemann Guenter

  公开号：US20070099910A1

  公开（公告）日：2007-05-03

  The invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X and X′ have the designations cited in patent claim 1. Said compounds are inhibitors of tyrosine kinases, especially TIE-2, and Raf kinases, and can, inter alia, be used for the treatment of tumours.

  该发明涉及式（I）的化合物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、X和X'具有专利权第1项中引用的指定。所述化合物是酪氨酸激酶抑制剂，特别是TIE-2和Raf激酶的抑制剂，并可用于治疗肿瘤等。
• PYRIDOPYRIMIDINONE ZUR BEHANDLUNG VON KREBSERKRANKUNGEN
  申请人：Merck Patent GmbH

  公开号：EP1682548B1

  公开（公告）日：2009-09-23
• Methods for modulating glutamate receptors for treating neuropsychiatric disorders comprising the use of modulators of serum and glucocorticoid inducible kinases
  申请人：Lang Florian

  公开号：US20070191326A1

  公开（公告）日：2007-08-16

  Modulation of the activity of serum and glucocorticoid inducible kinases to restore glutamate receptor activity. Also disclosed are methods and compounds useful for the detection and treatment of neuropsychiatric disorders.
• Methods For Interfering With Fibrosis
  申请人：Lang Florian

  公开号：US20070203085A1

  公开（公告）日：2007-08-30

  Modulation of the of glucocorticoid inducible kinases to restore Connective tissue growth factor activity. Also disclosed are methods and compounds useful for the detection and treatment of fibroproliferative disorders.
• US7547695B2
  申请人：——

  公开号：US7547695B2

  公开（公告）日：2009-06-16