N-ethylsulfonyl-D-phenylalanyl-N-[[4-(aminoiminomethyl)-3-hydroxyphenyl]methyl]-L-prolinamide hydrochloride | 201157-63-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-ethylsulfonyl-D-phenylalanyl-N-[[4-(aminoiminomethyl)-3-hydroxyphenyl]methyl]-L-prolinamide hydrochloride
• 英文别名: (2S)-N-[(4-carbamimidoyl-3-hydroxyphenyl)methyl]-1-[(2R)-2-(ethylsulfonylamino)-3-phenylpropanoyl]pyrrolidine-2-carboxamide;hydrochloride
• CAS: 201157-63-3
• 化学式: C₂₄H₃₁N₅O₅S*ClH
• 分子量: 538.068
• InChiKey: TZIJKCPLTTZOHV-FDOHDBATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.26
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• Anticoagulant agents
  申请人：——

  公开号：US20010018423A1

  公开（公告）日：2001-08-30

  This invention relates to a compound of the Formula I X-C(O)-Y-G-R   I (wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.

  本发明涉及一种公式IX-C（O）-Y-G-R的化合物（其中X，Y，G和R的值在说明中定义），或其药学上可接受的盐，制备此类化合物或盐的过程和中间体，包含该化合物或盐的制药组合物以及它们作为凝血酶抑制剂，凝血抑制剂和治疗血栓栓塞性疾病的药剂的使用方法。
• Trombin inhibitors as anticoagulant agents
  申请人：ELI LILLY AND COMPANY

  公开号：EP0816376A1

  公开（公告）日：1998-01-07

  This invention relates to a compound of the Formula I         X-C(O)-Y-G-R     I (wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.

  本发明涉及一种式 I 的化合物 X-C(O)-Y-G-R I (其中 X、Y、G 和 R 具有描述中定义的值）或其药学上可接受的盐、制备这种化合物或盐的工艺和中间体、包含这种化合物或盐的药物组合物以及将它们用作凝血酶抑制剂、凝血抑制剂和治疗血栓栓塞性疾病的药物的方法。
• Thrombininhibitors as anticoagulant agents
  申请人：Eli Lilly & Company

  公开号：EP1110968A1

  公开（公告）日：2001-06-27

  This invention relates to a compound of the Formula I         X-C(O)-Y-G-R     I (wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.

  本发明涉及一种式 I 的化合物 X-C(O)-Y-G-R I (其中 X、Y、G 和 R 具有描述中定义的值）或其药学上可接受的盐、制备这种化合物或盐的工艺和中间体、包含这种化合物或盐的药物组合物以及将它们用作凝血酶抑制剂、凝血抑制剂和治疗血栓栓塞性疾病的药物的方法。
• Intermediate for the preparation of Thrombininhibitors as anticoagulant agents
  申请人：Eli Lilly & Company

  公开号：EP1110968B1

  公开（公告）日：2003-10-01
• US6008367A
  申请人：——

  公开号：US6008367A

  公开（公告）日：1999-12-28