2-hydroxy-4-hexenoic acid | 109603-81-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-hydroxy-4-hexenoic acid
• 英文别名: (E)-2-hydroxyhex-4-enoic acid
• CAS: 109603-81-8
• 化学式: C₆H₁₀O₃
• 分子量: 130.144
• InChiKey: UPXKHUBIJAUPSR-NSCUHMNNSA-N

物化性质

• 沸点：
  282.7±20.0 °C(Predicted)
• 密度：
  1.144±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (1-甲基烯丙氧基)-乙酸 以85%的产率得到
  参考文献：
  名称：

  MIKAMI KOICHI; TAKAHASHI OSAMU; TABEI TATSUYA; NAKAI TAKESHI, TETRAHEDRON LETT., 27,(1986) N 37, 4511-4514

  摘要：

  DOI：

文献信息

• Novel silyl triflate-mediated “[2,3]wittig” sigmatropic rearrangement. The possible intervention of an oxygen ylide
  作者：Koichi Mikami、Osamu Takahashi、Tatsuya Tabei、Takeshi Nakai

  DOI：10.1016/s0040-4039(00)84992-8

  日期：——

  A novel silyl triflate-mediated [2,3]sigmatropic rearrangement of (allyloxy)acetates and their ketene silyl acetals is described, which is proposed to proceed via rarely precedented oxygen ylides. The formal [2,3]Wittlg shift is characterized by the unique stereoselectivity, , the rarely precedented -selectivity and the high erythro-selectivity.

  描述了一种新颖的三氟甲硅烷基介导的（烯丙氧基）乙酸酯及其烯酮甲硅烷基乙缩醛的[2,3]σ重排，其提议是通过很少先验的氧自由基进行的。形式上的[2,3] Wittlg位移的特征是独特的立体选择性，即极少先例的选择性和高赤型选择性。
• Cosmetic composition containing alpha hydroxy carboxylic acids as preservatives
  申请人：UNILEVER PLC

  公开号：EP0568307A1

  公开（公告）日：1993-11-03

  The use of at least 0.0001% by weight based on the total composition of an hydroxy organic acid having the structure (1): where    R is chosen from CxHy and CxHyOZ,    x is an integer of from 2 to 16,    y is an integer of from 5 to 53,    Z is chosen from -H,R' and (CH₂)n OR',    R' is chosen from CaHb and (CH₂)n OCaHb,    a is an integer of from 1 to 4,    b is an integer of from 2 to 9,    n is an integer of from 1 to 6. and mixtures thereof; as an inhibitor of microbial spoilage, together with a major amount of a cosmetically acceptable vehicle, in a composition intended for topical application to the human body.

  至少按照总成分重量的0.0001%使用具有结构（1）的羟基有机酸，其中：其中R选择自CₓHᵧ和CₓHᵧOZ，x为2至16的整数，y为5至53的整数，Z选择自-H、R'和（CH₂）n OR'，R'选择自CₐHᵇ和（CH₂）n OCaHᵇ，a为1至4的整数，b为2至9的整数，n为1至6的整数，以及它们的混合物；作为微生物腐败抑制剂，与大量的符合化妆标准的载体一起，在用于局部涂抹到人体的组合物中。
• Cosmetic composition
  申请人：UNILEVER PLC

  公开号：EP0442708A2

  公开（公告）日：1991-08-21

  The invention concerns 2-hydroxyalkenoic acids within a general formula where R′ is chosen from: a. CwH2w+1 b. CyH2y₋₁, and c. CyH2yOZ    where Z is chosen from H, R˝ and (CH₂)nOR˝       R˝ is chosen from CmH2m+1 and (CH₂)nOCmH2m+1;       w is an integer of from 1 to 25       y is an integer of from 2 to 25       m is an integer of from 1 to 4       n is an integer of from 1 to 6 Many compounds within the formula are novel and are claimed as such. The invention also provides a process for making the compounds, and compositions for topical application to human skin, hair or nails which contain compounds of the above formula and a cosmetically acceptable vehicle.

  本发明涉及通式如下的 2-羟基烯酸 其中R′选自 a.CwH2w+1 b.CyH2y₋₁, 和 c.CyH2yOZ 其中 Z 选自 H、R˝ 和 (CH₂)nOR˝ R˝ 选自 CmH2m+1 和 (CH₂)nOCmH2m+1； w 是 1 到 25 之间的整数 y 是 2 至 25 之间的整数 m 是 1 至 4 的整数 n 是 1 至 6 的整数 式中的许多化合物都是新颖的，因此提出权利要求。本发明还提供了一种制造上述化合物的工艺，以及用于人体皮肤、头发或指甲局部涂抹的组合物，该组合物含有上式化合物和一种化妆品可接受的载体。
• AGER, D. J.;COOKSON, R. C., TETRAHEDRON LETT., 1982, 23, N 33, 3419-3420
  作者：AGER, D. J.、COOKSON, R. C.

  DOI：——

  日期：——
• SYNERGISTIC PRESERVATIVE COMPOSITIONS
  申请人：ISP Investments LLC

  公开号：EP3288380A1

  公开（公告）日：2018-03-07