4-甲基环己醇乙酸酯 | 13332-20-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 4-甲基环己醇乙酸酯
• 英文名称: 1-Acetoxy-4-methyl-cyclohexan
• 英文别名: 4-Methylcyclohexanol acetate；(4-methylcyclohexyl) acetate
• CAS: 13332-20-2；22597-23-5
• 化学式: C₉H₁₆O₂
• mdl: MFCD00049178
• 分子量: 156.225
• InChiKey: VJBFCCCTSQEGMH-UHFFFAOYSA-N

物化性质

• 保留指数：
  1100;1111

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲基环己醇 以86%的产率得到
  参考文献：
  名称：

  Harrison John, Fuller Joseph C., Goralski Christian T., Singaram Bakthan, Tetrahedron Lett, 35 (1994) N 29, S 5201-5204

  摘要：

  DOI：

文献信息

• [EN] 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE LA 3-PHOSPHOGLYCÉRATE DÉSHYDROGÉNASE ET LEURS UTILISATIONS
  申请人：RAZE THERAPEUTICS INC

  公开号：WO2017156165A1

  公开（公告）日：2017-09-14

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用这些化合物的方法。
• Graphite oxide-catalyzed acetylation of alcohols and phenols
  作者：Yuan-Yuan Liu、Jun-Mei Qi、Li-Sha Bai、Yue-Long Xu、Ning Ma、Fei-Fei Sun

  DOI：10.1016/j.cclet.2016.01.005

  日期：2016.5

  Abstract Graphite oxide (GO) was used as a catalyst for the reactions of alcohols and phenols with acetic anhydride. The acetates of primary and secondary alcohols were prepared in good to excellent yields in short reaction time under mild conditions. Electron deficient phenols could be converted to the corresponding acetates steadily. As an efficient catalyst, GO is easily available, cheap, moderately toxic

  摘要氧化石墨（GO）被用作醇和酚与乙酸酐反应的催化剂。伯醇和仲醇的乙酸酯在温和的条件下以较短的反应时间以良好至极好的收率制备。缺电子的酚可以稳定地转化为相应的乙酸酯。作为一种有效的催化剂，GO易于获得，廉价，毒性适中且呈弱酸性。
• OXOPIPERIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
  申请人：Braun Alain

  公开号：US20070149562A1

  公开（公告）日：2007-06-28

  The present invention relates to compounds of formula (I) as defined herein that are melanocortin receptor agonists, to the preparation thereof and to the therapeutic use thereof in the treatment or prevention of a condition selected from obesity, diabetes and sexual dysfunctions that can affect both sexes, in the treatment of cardiovascular diseases, and also in anti-inflammatory uses or in the treatment of alcohol dependency.

  本发明涉及根据本文所定义的式（I）的化合物，这些化合物是黑色素皮质素受体激动剂，涉及其制备以及在治疗或预防肥胖、糖尿病和可能影响两性的性功能障碍中的治疗用途，治疗心血管疾病，以及抗炎症用途或治疗酒精依赖症。
• ALPHA-SUBSTITUTED VINYLTIN COMPOUND
  申请人：Tatsuta Kuniaki

  公开号：US20090023939A1

  公开（公告）日：2009-01-22

  To provide α-substituted vinyltin useful for the search for function-developing substances such as pharmaceuticals/agrichemicals and functional materials and for the construction of a compound library. An α-substituted vinyltin compound represented by the formula (1), a tautomer or salt of the compound or a solvate thereof: R 2 CH═C(R 3 )Sn(R 1 ) 3 (1) wherein R 1 is a C 1-10 alkyl group, a C 2-14 aryl group or the like, R 2 is a C 2-14 aryl group, a C 2-9 heterocyclyl group, a C 3-10 cycloalkyl group or the like, and R 3 is a carbamoyl group, a thiocarbamoyl group, an isocyanate group, an isothiocyanate group, a formylamino group, a thioformylamino group, an isonitrile group, an urea group, a carbamate group or the like.

  提供α-取代的乙烯基锡，用于寻找功能发展物质，如药物/农药和功能材料，以及用于构建化合物库。由下式表示的α-取代的乙烯基锡化合物（1）或其互变异构体或盐或溶剂合物：R2CH═C(R3)Sn(R1)3（1）其中R1是C1-10烷基，C2-14芳基或类似物，R2是C2-14芳基，C2-9杂环基，C3-10环烷基或类似物，R3是氨基甲酰基，硫氨基甲酰基，异氰酸酯基，异硫氰酸酯基，甲酰氨基基，硫代甲酰氨基基，异腈基，脲基，氨基甲酸酯基或类似物。
• Meerwein–Ponndorf–Verley-type reductive acetylation of carbonyl compounds to acetates by lanthanide complexes in the presence of isopropenyl acetate
  作者：Yasushi Nakano、Satoshi Sakaguchi、Yasutaka Ishii

  DOI：10.1016/s0040-4039(00)00012-5

  日期：2000.3

  Meerwein–Ponndorf–Verley-type reductive acetylation of carbonyl compounds to acetates was successfully carried out in the presence of isopropenyl acetate under the influence of a catalytic amount of Ln(OiPr)3 at room temperature. Various carbonyl compounds were converted into the corresponding acetates in fair to good yields.

  在室温下，在催化量Ln（O i Pr）3的影响下，在乙酸异丙烯酯的存在下，成功实现了Meerwein-Ponndorf-Verley型羰基化合物还原为乙酸的乙酰基化反应。各种羰基化合物均以适当的收率转化为相应的乙酸盐。