4-甲基茚满-5-醇 | 20294-38-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: 4-甲基茚满-5-醇
• 英文名称: 4-Methyl-indan-5-ol
• 英文别名: 4-Methylindan-5-ol；4-methyl-2,3-dihydro-1H-inden-5-ol
• CAS: 20294-38-6
• 化学式: C₁₀H₁₂O
• 分子量: 148.205
• InChiKey: BVKUYBCYSJOQLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2906299090

反应信息

• 作为产物：
  描述：

  2-(3-Oxobutan-2-yl)cyclopentene-1-carbaldehyde 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以80%的产率得到4-甲基茚满-5-醇
  参考文献：
  名称：

  芳香退火。二。酚的合成。

  摘要：

  描述了通过芳香环的精制由环烷酮制备取代的酚的方法。

  DOI：

  10.1016/s0040-4039(00)88422-1

文献信息

• The generation of 2-vinylcyclopentene-1,3-diones via a five-component coupling in the coordination sphere of chromium
  作者：Yao Chang Xu、Cynthia A. Challener、Vera Dragisich、Timothy A. Brandvold、Glen A. Peterson、William D. Wulff、Paul G. Williard

  DOI：10.1021/ja00200a062

  日期：1989.8

  La reaction de complexes carbenes de chrome pentacarbonyle avec des derives de l'acetylene donne des cyclopentenes-2diones-1,4, des indanols et indanones

  La 反应 de complexes carbenes de chrome pentacarbonyle avec des 衍生 de l'acetene donne des cyclopentenes-2diones-1,4, des indanols et indanones
• Synthesis of substituted phenols Via photoaddition-fragmentation-aromatic annelation sequence
  作者：Nizar Haddad、Irina Kuzmenkov

  DOI：10.1016/0040-4039(96)00083-4

  日期：1996.3

  Intramolecular photocycloaddition reaction of dihyro-4-pyrones to alkenes (1), followed by fragmentation then subsequent aromatic annelation, carried out by two alternative methods, has been performed efficiently. The sequence provides a convenient method for the construction of substituted phenols fused to aliphatic ring (4).

  二氢-4-吡喃酮与烯烃的分子内光环加成反应（1），然后进行断裂，然后通过两种替代方法进行的随后的芳族芳构化反应已得到有效执行。该序列为构建与脂族环（4）稠合的取代酚提供了便利的方法。
• Enynones in Organic Synthesis. 8. Synthesis of the Antimicrobial-Cytotoxic Agent Juncusol and Members of the Effusol Class of Phenols
  作者：Peter A. Jacobi、Joseph I. Kravitz、Wanjun Zheng

  DOI：10.1021/jo00107a017

  日期：1995.1

  Two new syntheses of phenols have been developed which have been utilized in an efficient preparation of the antimicrobial-cytotoxic agent juncusol (22) and several members of the effusol (23) class of phenols. These results complement our earlier studies with enynones of type 42 and provide for the highly efficient conversion of 42 to either methylenecyclopentenones 45 or phenols of type 47 or 54 with virtually 100% selectivity.
• Enynones in organic synthesis. III. A novel synthesis of phenols
  作者：Peter A. Jacobi、Joseph I. Kravitz

  DOI：10.1016/s0040-4039(00)88463-4

  日期：1988.1
• Synthesis and Thermolysis of Enediynyl Ethyl Ethers as Precursors of Enyne−Ketenes
  作者：Anna Tarli、Kung K. Wang

  DOI：10.1021/jo971391b

  日期：1997.12.1

  Enediynyl ethyl ethers 14/17 were synthesized by using the Pd(PPh3)(4)-catalyzed cross-coupling reactions between enynyl iodides 13/16 and (2-ethoxyethynyl)zinc chloride. Thermolysis of these enediynyl ethyl ethers in refluxing chlorobenzene (132 degrees C) promoted a retro-ene reaction to produce enyne-ketenes, which underwent the Moore cyclization reactions to form the biradicals having a phenyl radical center and a phenoxy radical center. The presence of two radical centers in the same molecule simultaneously provided many opportunities for intramolecular decay through disproportionation, radical-radical combination, and the formation of o-quinone methide.