3-Phenyl-2-carbamoyl-oxaziridin | 2289-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Phenyl-2-carbamoyl-oxaziridin
• 英文别名: 3-Phenyloxaziridine-2-carboxamide
• CAS: 2289-98-7
• 化学式: C₈H₈N₂O₂
• 分子量: 164.164
• InChiKey: GBLWFOAQFJHFPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Phenyl-2-carbamoyl-oxaziridin 、 甲基肼 以 四氢呋喃 为溶剂， 生成 2-Methyl-triazan-1-carbonamid
  参考文献：
  名称：

  Schmitz,E. et al., Angewandte Chemie, 1966, vol. 78, p. 587 - 588

  摘要：

  DOI：

文献信息

• [EN] NOVEL METHIONINE CONTAINING ANTIBODIES FOR CONJUGATION OF AGENTS<br/>[FR] NOUVEAUX ANTICORPS CONTENANT DE LA MÉTHIONINE POUR LA CONJUGAISON D'AGENTS
  申请人：UNIV CALIFORNIA

  公开号：WO2020140123A1

  公开（公告）日：2020-07-02

  Provided herein are novel antibody-agent conjugates formed by the introduction of methionine residues to antibody scaffold light or heavy chains at select positions, followed by conjugation of the agent to the methionine, for example, by oxaziridine chemistries. Methionine substitutions at the targeted positions enable highly efficient functionalization to form very stable conjugates, including conjugates suitable for in vivo use. The positions were identified for the trastuzumab and other related scaffolds which can be engineered for affinity to any target antigen. The conjugates include ADCs and detections agents. Also disclosed are novel oxaziridine reagents for conjugation to methionines in proteins.