N-(3-nitrophenylmethyl)thiomorpholine | 237432-09-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-nitrophenylmethyl)thiomorpholine
• 英文别名: Cambridge id 5267099；4-[(3-nitrophenyl)methyl]thiomorpholine
• CAS: 237432-09-6
• 化学式: C₁₁H₁₄N₂O₂S
• 分子量: 238.31
• InChiKey: ZRUOBZXHWOQHIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  74.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(3-nitrophenylmethyl)thiomorpholine 在 palladium on activated charcoal 氢气 作用下， 以99%的产率得到3-(Thiomorpholin-4-ylmethyl)aniline
  参考文献：
  名称：

  Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives

  摘要：

  Novel toluidine derivatives are described. Some of them showed an interesting in vitro activity against Mycobacterium tuberculosis, M. smegmatis, M. marinum, M. gordonae, and M. avium. Some of them were more active than Streptomycin and Isoniazid, which were used as controls, against M. avium and M. gordonae. In particular, we confirm the good activity of biphenyl derivatives. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00084-1
• 作为产物：
  描述：

  硫代吗啉 、 间硝基氯化苄 在 potassium carbonate 、 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 1.5h， 以76%的产率得到N-(3-nitrophenylmethyl)thiomorpholine
  参考文献：
  名称：

  Mai, Antonello; Sbardella, Gianluca; Artico, Marino, Medicinal Chemistry Research, 1999, vol. 9, # 3, p. 149 - 161

  摘要：

  DOI：

文献信息

• Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives
  作者：Mariangela Biava、Rossella Fioravanti、Giulio Cesare Porretta、Giancarlo Sleiter、Delia Deidda、Giorgio Lampis、Raffaello Pompei

  DOI：10.1016/s0014-827x(99)00084-1

  日期：1999.11

  Novel toluidine derivatives are described. Some of them showed an interesting in vitro activity against Mycobacterium tuberculosis, M. smegmatis, M. marinum, M. gordonae, and M. avium. Some of them were more active than Streptomycin and Isoniazid, which were used as controls, against M. avium and M. gordonae. In particular, we confirm the good activity of biphenyl derivatives. (C) 1999 Elsevier Science S.A. All rights reserved.
• Mai, Antonello; Sbardella, Gianluca; Artico, Marino, Medicinal Chemistry Research, 1999, vol. 9, # 3, p. 149 - 161
  作者：Mai, Antonello、Sbardella, Gianluca、Artico, Marino、Massa, Silvio、Lampis, Giorgio、Deidda, Delia、Pompeit, Raffaello

  DOI：——

  日期：——