3-benzoyl-1-methylpyrimidine-2,4-dione | 4330-19-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-benzoyl-1-methylpyrimidine-2,4-dione
• 英文别名: 1-Methyl-3-benzoyl-uracil；3-benzoyl-1-methyluracil；3-benzoyl-1-methyl-1H-pyrimidine-2,4-dione
• CAS: 4330-19-2
• 化学式: C₁₂H₁₀N₂O₃
• 分子量: 230.223
• InChiKey: PTRLQMXNIDXARD-UHFFFAOYSA-N

物化性质

• 熔点：
  150-152 °C
• 沸点：
  363.4±25.0 °C(Predicted)
• 密度：
  1.339±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-benzoyl-1-methylpyrimidine-2,4-dione 在 氨 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以100%的产率得到1-甲基尿嘧啶
  参考文献：
  名称：

  SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

  摘要：

  公开号：

  EP3412660B9
• 作为产物：
  描述：

  苯甲酰氯 在 吡啶 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 28.67h， 生成 3-benzoyl-1-methylpyrimidine-2,4-dione
  参考文献：
  名称：

  C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells

  摘要：

  The K562 cell line has been proposed as a useful experimental system to identify anti-tumor compounds acting by inducing terminal erythroid differentiation. K562 cells exhibit a low proportion of hemoglobin-synthesizing cells under standard cell growth conditions, but are able to undergo terminal erythroid differentiation when treated with a variety of anti-tumor compounds. In this paper we report a screening study on a set of different modified C(5) uracil derivatives for the evaluation of their antiproliferative effect in connection with erythroid differentiation pathways, and for defining a new class of drug candidates for the treatment of chronic myelogenous leukemia. Activity of the derivatives tested can be classified in two effect: an antiproliferative effect linked to a high level of erythroid differentiation activity and an antiproliferative effect without activation of gamma globin genes The highest antiproliferative effect and erythroid induction was shown by compound 9, a thymine derivative bearing a n-octyl chain on nitrogen N(1), whereas thymine did not show any effect, suggesting the importance of the linear alkyl chain in position N(1). To our knowledge this compound should be considered among the most efficient inducers of erythroid differentiation of K562 cells. This work is the starting point for the quest of more effective and specific drugs for the induction of terminal erythroid differentiation, for leading new insights in the treatment of neoplastic diseases with molecules acting by inducing differentiation rather than by simply exerting cytotoxic effects. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ejphar.2011.09.024

文献信息

• OLIGONUCLEOTIDE WITH PROTECTED BASE
  申请人：Ajinomoto Co., Inc.

  公开号：US20150080565A1

  公开（公告）日：2015-03-19

  The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.

  本发明提供了一种用于延伸的保护核苷酸，可以通过液液萃取操作高效率、高产量地纯化，并可通过磷酰胺酰胺法实现寡核苷酸的生产方法。发现通过在3'-位置含有支链含芳香基团的特定寡核苷酸和/或特定寡核苷酸保护基，可以解决上述问题。
• Substituted benzenesulfonamides as inhibitors of alpha-4 beta-7 integrin activity
  申请人：EA PHARMA CO., LTD.

  公开号：US10562898B2

  公开（公告）日：2020-02-18

  Provided is a compound having α4 integrin inhibitory action. The compound is a sulfonamide derivative represented by the following formula (I), or pharmaceutically acceptable salt thereof: where R1 to R5, e to h, D, and B represent those as described in the specification.

  本发明提供了一种具有α4整合素抑制作用的化合物。 该化合物是由下式（I）代表的磺酰胺衍生物，或其药学上可接受的盐： 其中 R1 至 R5、e 至 h、D 和 B 代表说明书中所述的那些。
• Compounds and Methods of Making Compounds
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20150118157A1

  公开（公告）日：2015-04-30

  Embodiments of the present disclosure provide for compounds and methods of making compounds such as those shown in FIGS. 1.1A and 1.1B having formula 2, 3, 4, 5, 11, and 12 and formula 2′, 4′, and 11′,as well as uses for the compounds for imaging, and the like.
• US8846885B2
  申请人：——

  公开号：US8846885B2

  公开（公告）日：2014-09-30
• US9011817B2
  申请人：——

  公开号：US9011817B2

  公开（公告）日：2015-04-21