4-(4'-chloro-biphenyl-4-yl)-1-pyrimidin-2-yl-piperidin-4-ol | 914807-79-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(4'-chloro-biphenyl-4-yl)-1-pyrimidin-2-yl-piperidin-4-ol
• 英文别名: 4-[4-(4-Chlorophenyl)phenyl]-1-pyrimidin-2-ylpiperidin-4-ol
• CAS: 914807-79-7
• 化学式: C₂₁H₂₀ClN₃O
• 分子量: 365.862
• InChiKey: QGEQQYGRNQGBGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  49.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Multicyclic compounds and methods of their use
  申请人：Barbosa Joseph

  公开号：US20060258672A1

  公开（公告）日：2006-11-16

  This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.

  这项发明涉及多环化合物，包括它们的药物组合物，以及它们在治疗认知障碍等方面的使用方法。
• Methods and compositions for improving cognition
  申请人：Barbosa Joseph

  公开号：US20060258691A1

  公开（公告）日：2006-11-16

  This invention encompasses methods of improving cognitive performance and of treating, preventing and managing various diseases and disorders, such as Alzheimer's disease, autism, cognitive disorders, dementia, learning disorders, and short- and long-term memory loss.

  这项发明涵盖了改善认知表现的方法，以及治疗、预防和管理各种疾病和障碍，如阿尔茨海默病、自闭症、认知障碍、痴呆症、学习障碍以及短期和长期记忆丧失。
• Methods of Treating Cognitive Impairment and Dementia
  申请人：Barbosa Joseph

  公开号：US20080153811A1

  公开（公告）日：2008-06-26

  This invention relates to methods for treating, managing and preventing cognitive impairment associated with various diseases and disorders, age-associated memory impairment, and dementia.

  本发明涉及用于治疗、管理和预防与各种疾病和障碍相关的认知障碍、与年龄相关的记忆障碍和痴呆症的方法。
• METHODS OF TREATING SCHIZOPHRENIA
  申请人：Barbosa Joseph

  公开号：US20090306100A1

  公开（公告）日：2009-12-10

  This invention relates to methods for treating, managing and preventing cognitive impairment associated with various diseases and disorders, age-associated memory impairment, and dementia.

  本发明涉及用于治疗、管理和预防与各种疾病和障碍相关的认知障碍，年龄相关的记忆障碍和痴呆症的方法。
• MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE
  申请人：Barbosa Joseph

  公开号：US20100081691A1

  公开（公告）日：2010-04-01

  This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.

  本发明涉及多环化合物、包含它们的药物组合物以及它们在治疗认知障碍等方面的使用方法。