3-(2,2-Difluoroethyl)morpholine | 1803607-74-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-(2,2-Difluoroethyl)morpholine
• CAS: 1803607-74-0
• 化学式: C₆H₁₁F₂NO
• mdl: MFCD28397338
• 分子量: 151.15
• InChiKey: SLBJBODOVHXGPG-UHFFFAOYSA-N

物化性质

• 沸点：
  180.9±25.0 °C(Predicted)
• 密度：
  1.061±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN<br/>[FR] COMPOSÉS POUR L'INHIBITION DE L'INTÉGRINE ALPHA 4 BÊTA 7
  申请人：GILEAD SCIENCES INC

  公开号：WO2021030438A1

  公开（公告）日：2021-02-18

  The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), therapeutic methods for treating inflammatory disease.

  本公开提供了化合物的化学式(I)：或其药用可接受的盐，如本文所述。本公开还提供了包含化合物的药物组合物的配方(I)，制备化合物的方法(I)，治疗炎症性疾病的治疗方法。
• Quinoline derivatives
  申请人：Gilead Sciences, Inc.

  公开号：US11116760B2

  公开（公告）日：2021-09-14

  The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

  本公开提供了一种式 (I) 的化合物： 或其药学上可接受的盐。本公开还提供了包含式（I）化合物的药物组合物、制备式（I）化合物的工艺以及治疗炎症性疾病的治疗方法。
• QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS
  申请人：GILEAD SCIENCES, INC.

  公开号：EP3873884A1

  公开（公告）日：2021-09-08
• COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN
  申请人：GILEAD SCIENCES, INC.

  公开号：EP4013499A1

  公开（公告）日：2022-06-22
• QUINOLINE DERIVATIVES
  申请人：Gilead Sciences, Inc.

  公开号：US20200155538A1

  公开（公告）日：2020-05-21

  The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.