5-oxo-5H-thieno[3,2-b]pyran-6-carboxylic acid | 49596-82-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 5-oxo-5H-thieno[3,2-b]pyran-6-carboxylic acid
• 英文别名: 5-Oxothieno[3,2-b]pyran-6-carboxylic acid
• CAS: 49596-82-9
• 化学式: C₈H₄O₄S
• 分子量: 196.183
• InChiKey: FYVOABAXPTUOPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• BICYCLIC ENONE CARBOXYLATES AS MODULATORS OF TRANSPORTERS AND USES THEREOF
  申请人：NIROGYONE THERAPEUTICS, INC.

  公开号：US20210053982A1

  公开（公告）日：2021-02-25

  The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.
• [EN] BICYCLIC ENONE CARBOXYLATES AS MODULATORS OF TRANSPORTERS AND USES THEREOF<br/>[FR] CARBOXYLATES D'ÉNONE BICYCLIQUES UTILISÉS EN TANT QUE MODULATEURS DE TRANSPORTEURS ET LEURS UTILISATIONS
  申请人：SANDANAYAKA VINCENT

  公开号：WO2019191599A1

  公开（公告）日：2019-10-03

  The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.