6,6'-dimethoxy-2,2'-(piperazine-1,4-diylbismethylene)diphenol | 24773-90-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 6,6'-dimethoxy-2,2'-(piperazine-1,4-diylbismethylene)diphenol
• 英文别名: 6,6'-dimethoxy-2,2'-piperazine-1,4-diyldimethyl-bis-phenol；2-[[4-[(2-Hydroxy-3-methoxyphenyl)methyl]piperazin-1-yl]methyl]-6-methoxyphenol
• CAS: 24773-90-8
• 化学式: C₂₀H₂₆N₂O₄
• 分子量: 358.437
• InChiKey: AVTWMCSXYCYPLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  65.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6,6'-dimethoxy-2,2'-(piperazine-1,4-diylbismethylene)diphenol 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 反应 48.0h， 以90%的产率得到3,3'-(piperazine-1,4-diylbismethylene)di(benzene-1,2-diol)
  参考文献：
  名称：

  摘要：

  The synthesis of a number of novel dibenzene-1,2-diol Mannich bases can be achieved in good yields by the condensation of 2-methoxyphenol, formaldehyde and secondary diamines. The newly developed synthetic method utilizes 2-methoxyphenol instead of benzene-1,2-diol providing a useful tool for greater control over reaction products.

  DOI：

  10.1071/ch00079
• 作为产物：
  描述：

  哌嗪 、 聚合甲醛 、 木榴油 以 乙醇 为溶剂， 反应 96.0h， 以31%的产率得到6,6'-dimethoxy-2,2'-(piperazine-1,4-diylbismethylene)diphenol
  参考文献：
  名称：

  摘要：

  The synthesis of a number of novel dibenzene-1,2-diol Mannich bases can be achieved in good yields by the condensation of 2-methoxyphenol, formaldehyde and secondary diamines. The newly developed synthetic method utilizes 2-methoxyphenol instead of benzene-1,2-diol providing a useful tool for greater control over reaction products.

  DOI：

  10.1071/ch00079

文献信息

• Benzene-1 2-diol mannich bases ligands polymers and method of selective metal ions removal
  申请人：——

  公开号：US20040138488A1

  公开（公告）日：2004-07-15

  A complexing ligand for forming a complex with a cation, the ligand comprising an aromatic component including two or more attachment sites for the cation, an optionally substituted amine, such as an aminoalkylene group, and a hydrocarbon chain of from 1 to 12 carbon atoms in length. The amine component of the ligand is capable of taking on an internal counterion (H+) so that the complex of the target cation and ligand has an overall neutral charge. Such ligands can be used to extract a target cation or cations from an aqueous solution. This has particular application for the separation of aluminium and silicon in aqueous liqors in a Bayer process. The ligand can be a simple compound formed by the Mannich condensation of catechol with formaldehyde and an amine. The ligand may alternatively be a bis-ligand, a polymer or an ion exchange resin. A range of new compounds and intermediates are also described.

  一种用于与阳离子形成络合物的络合配体，该配体包括一个包括两个或多个阳离子附着位点的芳香族组分、一个任选取代的胺，如氨基烷基，以及一个长度为 1 至 12 个碳原子的烃链。配体中的胺成分能够吸收内部反离子（H+），从而使目标阳离子和配体的复合物具有整体中性电荷。这种配体可用于从水溶液中萃取目标阳离子。这种方法特别适用于拜耳法分离水溶液中的铝和硅。配体可以是儿茶酚与甲醛和胺的曼尼希缩合反应形成的简单化合物。配体也可以是双配体、聚合物或离子交换树脂。此外，还介绍了一系列新化合物和中间体。
• EP1366015A4
  申请人：——

  公开号：EP1366015A4

  公开（公告）日：2008-03-26
• BENZENE-1 2-DIOL MANNICH BASES LIGANDS POLYMERS AND METHOD OF SELECTIVE METAL IONS REMOVAL
  申请人：TECHNOLOGICAL RESOURCES PTY. LTD.

  公开号：EP1366015A1

  公开（公告）日：2003-12-03
• [EN] BENZENE-1 2-DIOL MANNICH BASES LIGANDS POLYMERS AND METHOD OF SELECTIVE METAL IONS REMOVAL<br/>[FR] BASES DE MANNICH DE BENZENE-1 2-DIOL, LIGANDS, POLYMERES, ET METHODE D'ELIMINATION SELECTIVE D'IONS METALLIQUES
  申请人：TECH RESOURCES PTY LTD

  公开号：WO2002070456A1

  公开（公告）日：2002-09-12

  A complexing ligand for forming a complex with a cation, the ligand comprising an aromatic component including two or more attachment sites for the cation, an optionally substituted amine, such as an aminoalkylene group, and a hydrocarbon chain of from 1 to 12 carbon atoms in length. The amine component of the ligand is capable of taking on an internal counterion (H+) so that the complex of the target cation and ligand has an overall neutral charge. Such ligands can be used to extract a target cation or cations from an aqueous solution. This has particular application for the separation of aluminium and silicon in aqueous liqors in a Bayer process. The ligand can be a simple compound formed by the Mannich condensation of catechol with formaldehyde and an amine. The ligand may alternatively be a bis-ligand, a polymer or an ion exchange resin. A range of new compounds and intermediates are also described.
• ——
  作者：Marcus J. Caulfield、Tiziana Russo、David H. Solomon

  DOI：10.1071/ch00079

  日期：——

  The synthesis of a number of novel dibenzene-1,2-diol Mannich bases can be achieved in good yields by the condensation of 2-methoxyphenol, formaldehyde and secondary diamines. The newly developed synthetic method utilizes 2-methoxyphenol instead of benzene-1,2-diol providing a useful tool for greater control over reaction products.