2'-deoxy-2',2'-difluorocytidine-5'-monophosphate tri-butylammonium salt | 1129491-89-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2'-deoxy-2',2'-difluorocytidine-5'-monophosphate tri-butylammonium salt
• CAS: 1129491-89-9
• 化学式: C₉H₁₂F₂N₃O₇P*C₁₂H₂₇N
• 分子量: 528.534
• InChiKey: MPPDSPIAKDLPSF-YPWTWYSKSA-N

反应信息

• 作为反应物：
  描述：

  、 2'-deoxy-2',2'-difluorocytidine-5'-monophosphate tri-butylammonium salt 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 P¹-5'-[5-(2-bromovinyl)-2'-deoxyuridine]-P²-5'-[2'-deoxy-2',2'-difluorocytidine]pyrophosphate
  参考文献：
  名称：

  Synthesis and Antitumor Activity of a Heterodinucleotide of BVDU and Gemcitabine

  摘要：

  A heterodinucleotide comprising BVDU and Gemcitabine bound together by a 5',5'-pyrophospate bridge (BVDUp(2)dFdC) has been synthesized and evaluated as antitumor agent against AH13 rat sarcoma cells. BVDUp(2)dFdC showed a cytotoxicity similar to that of Gemcitabine.

  DOI：

  10.1080/15257770802088787