1,7-bis(tert-butoxycarbonylmethyl)-4,10-bis{[N-(di(2-picolyl)aminoethyl)carbamoyl]methyl}-1,4,7,10-tetraazacyclododecane | 1174435-88-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,7-bis(tert-butoxycarbonylmethyl)-4,10-bis{[N-(di(2-picolyl)aminoethyl)carbamoyl]methyl}-1,4,7,10-tetraazacyclododecane
• CAS: 1174435-88-1
• 化学式: C₅₂H₇₆N₁₂O₆
• 分子量: 965.252
• InChiKey: OHTWLILHNDCYOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 拓扑面积：
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文献信息

• Selective labeling of tag-fused protein by tryptophan-sensitized luminescence of a terbium complex
  作者：Tasuku Hirayama、Masayasu Taki、Atsushi Kodan、Hiroaki Kato、Yukio Yamamoto

  DOI：10.1039/b900302a

  日期：——

  A Tb3+ complex with two di(2-picolyl)amine (DPA) moieties and an oligo-aspartate peptide containing a tryptophan residue have been designed as a new binding pair for use in protein labeling.

  设计了一种含有两个二(2-吡啶基)胺（DPA）部分和一个包含色氨酸残基的寡天冬氨酸肽的Tb3+复合物，作为用于蛋白质标记的新型结合对。
• A New Gadolinium-Based MRI Zinc Sensor
  作者：Ana C. Esqueda、Jorge A. López、Gabriel Andreu-de-Riquer、José C. Alvarado-Monzón、James Ratnakar、Angelo J. M. Lubag、A. Dean Sherry、Luis M. De León-Rodríguez

  DOI：10.1021/ja901875v

  日期：2009.8.19

  The properties of a novel Gd3+-based MRI zinc sensor are reported. Unlike previously reported Gd3+-based MRI contrast agents, this agent (GdL) differs in that the agent alone binds only weakly with human serum albumin (HSA), while the 1:2 GdL:Zn2+ ternary complex binds strongly to HSA resulting in a substantial, 3-fold increase in water proton relaxivity. The GdL complex is shown to have a relatively strong binding affinity for Zn2+ (K-D = 33.6 nM), similar to the affinity of the Zn2+ ion with HSA alone. The agent detects as little as 30 mu M Zn2+ in the presence of HSA by MRI in vitro, a value slightly more than the total Zn2+ concentration in blood (similar to 20 mu M). This combination of binding affinity constants and the high relaxivity of the agent when bound to HSA suggests that this new agent may be useful for detection of free Zn2+ ions in vivo without disrupting other important biological processes involving Zn2+.