N 0498 | 92422-19-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N 0498
• 英文别名: trans-N-n-propyl-2,3,4a,5,6,10b-hexahydro-4H-naphth[1,2b][1,4]oxazine；trans-4-(n-Propyl)-2,3,4a,5,6,10b-hexahydro-4h-naphth[1,2-b][1,4]-oxazine；(4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazine
• CAS: 92422-19-0
• 化学式: C₁₅H₂₁NO
• 分子量: 231.338
• InChiKey: AWZLBZREVQLYFE-HUUCEWRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4aR,10bR)-3,4,4a,5,6,10b-hexahydro-2H-benzo[h][1,4]benzoxazine 生成 N 0498
  参考文献：
  名称：

  JONES, J. H.

  摘要：

  DOI：

文献信息

• Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists
  作者：James H. Jones、Paul S. Anderson、John J. Baldwin、Bradley V. Clineschmidt、David E. McClure、George F. Lundell、William C. Randall、Gregory E. Martin、Michael Williams

  DOI：10.1021/jm00378a014

  日期：1984.12

  A series of tricyclic oxazines, namely, the 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, have been synthesized and assayed for dopamine agonist activity. One of the members of this series, compound (+)VII-15, was found to be a remarkably potent agonist in vivo when tested in the standard 6-hydroxydopamine lesioned rat assay. The absolute configuration of the compound corresponds to that found in the active isomer of apomorphine. Its activity at the alpha 2 receptor (vs. [3H]clonidine) is relatively low. It also failed to stimulate the synthesis of cAMP in the carp retina assay, thus giving the compound a highly selective profile in favor of the D2 receptor.
• DYKSTRA, D.;HAZELHOFF, B.;MULDER, T. B. A.;VRIES, J. B. DE;WYNBERG, H.;HO+, EUR. J. MED. CHEM., 1985, 20, N 3, 247-250
  作者：DYKSTRA, D.、HAZELHOFF, B.、MULDER, T. B. A.、VRIES, J. B. DE、WYNBERG, H.、HO+

  DOI：——

  日期：——