(N-2-hydroxyethyl)phenylalanine | 21768-52-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (N-2-hydroxyethyl)phenylalanine
• 英文别名: N-<2-Hydroxy-aethyl>-phenylalanin；2-(2-Hydroxyethylamino)-3-phenylpropanoic acid
• CAS: 21768-52-5
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: GXDTZRUJRGFTRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (N-2-hydroxyethyl)phenylalanine 生成 N-<2-Hydroxy-aethyl>-phenylalaninaethylester
  参考文献：
  名称：

  Giraud-Clenet,D.; Anatol,J., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1969, vol. 268, p. 117 - 120

  摘要：

  DOI：
• 作为产物：
  描述：

  α-<2-Hydroxy-aethylamino>-β-phenyl-propionsaeurenitril 在 盐酸 作用下， 生成 (N-2-hydroxyethyl)phenylalanine
  参考文献：
  名称：

  Giraud-Clenet,D.; Anatol,J., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1969, vol. 268, p. 117 - 120

  摘要：

  DOI：

文献信息

• Asymmetric Reductive Amination of α-Keto Acids Using Ir-Based Hydrogen Transfer Catalysts: An Access to Unprotected Unnatural α-Amino Acids
  作者：Takaaki Yajima、Akito Katayama、Tsubasa Ito、Takuma Kawada、Kenya Yabushita、Toshihisa Yasuda、Takeshi Ohta、Takeaki Katayama、Noriyuki Utsumi、Yoshihito Kayaki、Shigeki Kuwata

  DOI：10.1021/acs.orglett.3c04378

  日期：2024.2.23

  A direct asymmetric reductive amination of α-keto acids catalyzed by Cp*Ir complexes bearing a chiral N-(2-picolyl)sulfonamidato ligand is described. The combined use of optically active 2-phenyglycinol as an aminating agent is effective for the chemo- and stereoselective transfer hydrogenation using formic acid. The subsequent elimination of the hydroxyethyl moiety by orthoperiodic acid can afford

  描述了由带有手性N- (2-吡啶甲基)磺酰胺基配体的 Cp*Ir 配合物催化的 α-酮酸的直接不对称还原胺化。组合使用光学活性2-苯甘氨醇作为胺化剂对于使用甲酸的化学选择性和立体选择性转移氢化是有效的。随后用原高碘酸消除羟乙基部分可以以令人满意的分离产率（20个实例）提供各种未保护的α-氨基酸，并具有优异的光学纯度（高达> 99% ee）。
• METHODS FOR MAKING EMBRYONIC CELLS, EMBRYOS, AND ANIMALS SENSITIZED TO STRESS
  申请人：Wangh Lawrence J.

  公开号：US20120198576A1

  公开（公告）日：2012-08-02

  Embodiments of the invention are based upon the discovery that exposure of cleavage-stage embryos to a stress inducer, e.g. heat shock or chemical, renders the exposed embryos more sensitive to a secondary treatment with a stress inducer, e.g. heat shock or chemical inducer. Accordingly, the present invention is directed to methods for making embryos, embryonic cells arising from them, and animals and plants that are sensitized to stress, e.g. physiologic or chemical stressors. Methods of screening for inducers and inhibitors of stress using, as test model systems, embryonic cells, embryos, animals, and plants that are sensitized to stress are also disclosed.
• [EN] METHODS FOR MAKING EMBRYONIC CELLS, EMBRYOS, AND ANIMALS SENSITIZED TO STRESS<br/>[FR] PROCÉDÉS DE FABRICATION DE CELLULES EMBRYONNAIRES, EMBRYONS, ET ANIMAUX SENSIBILISÉS AU STRESS
  申请人：UNIV BRANDEIS

  公开号：WO2011002955A2

  公开（公告）日：2011-01-06

  Embodiments of the invention are based upon the discovery that exposure of cleavage-stage embryos to a stress inducer, e.g. heat shock or chemical, renders the exposed embryos more sensitive to a secondary treatment with a stress inducer, e.g. heat shock or chemical inducer. Accordingly, the present invention is directed to methods for making embryos, embryonic cells arising from them, and animals and plants that are sensitized to stress, e.g. physiologic or chemical stressors. Methods of screening for inducers and inhibitors of stress using, as test model systems, embryonic cells, embryos, animals, and plants that are sensitized to stress are also disclosed.