valeroyloxyacetaldehyde | 547753-11-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: valeroyloxyacetaldehyde
• 英文别名: 2-Oxoethyl pentanoate
• CAS: 547753-11-7
• 化学式: C₇H₁₂O₃
• 分子量: 144.17
• InChiKey: QRUJNEDWBUQOMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SPIRO-OXINDOLE MDM2 ANTAGONISTS
  申请人：Wang Shaomeng

  公开号：US20110112052A1

  公开（公告）日：2011-05-12

  Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

  本文提供了关于药物化学领域的化合物、组合物和方法。本文提供的化合物和组合物涉及作为p53和MDM2相互作用拮抗剂的螺环氧吲哌酮，并且它们作为治疗癌症和其他疾病的药物的用途。
• Preparation of intermediates useful in the synthesis of antiviral nucleosides
  申请人：——

  公开号：US20030162992A1

  公开（公告）日：2003-08-28

  The present invention is an efficient process for the manufacture of &agr;-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

  本发明是一种制备&agr;-酰氧基乙醛的高效过程，该化合物是合成1,3-噻二环己烷和1,3-二氧杂环己烷核苷的关键中间体。
• Method of manufacture of 1,3-oxathiolane nucleosides
  申请人：GILEAD SCIENCES, INC.

  公开号：EP1535921A1

  公开（公告）日：2005-06-01

  Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.

  提供了制备1,3-氧硫杂环嘧啶核苷的过程，其中包括制备1,3-氧硫杂环环的高效方法以及将1,3-氧硫杂环与嘧啶或嘌呤碱基进行后续缩合的方法。使用本文所述的过程，可以提供单体对映体化合物。
• [EN] METHOD OF MANUFACTURE OF 1,3-OXATHIOLANE NUCLEOSIDES<br/>[FR] METHODE DE PRODUCTION DE NUCLEOSIDES DE 1,3-OXATHIOLANE
  申请人：TRIANGLE PHARMACEUTICALS INC

  公开号：WO2000009494A1

  公开（公告）日：2000-02-24

  Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.

  提供了制备1,3-氧硫杂环核苷的过程，其中包括制备1,3-氧硫杂环环的高效方法以及将1,3-氧硫杂环与嘧啶或嘌呤碱基进行缩合的后续步骤。使用本文所描述的过程，这些化合物可以作为分离的对映体提供。
• Small molecule inhibitors of MDM2 and the uses thereof
  申请人：Wang Shaomeng

  公开号：US20060211757A1

  公开（公告）日：2006-09-21

  The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

  这项发明涉及小分子，其作为p53和MDM2之间相互作用的抑制剂。该发明还涉及使用这些化合物来抑制细胞生长、诱导细胞死亡、诱导细胞周期停滞和/或使细胞对其他药物敏感。