(1R,5S)-N-(2-methoxyacetyl)-1,2,3,4,5,6-hexahydro-1,5-methanopyrido[1,2-a]diazocin-8-one | 881853-39-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 羽扇豆生物碱
• 英文名称: (1R,5S)-N-(2-methoxyacetyl)-1,2,3,4,5,6-hexahydro-1,5-methanopyrido[1,2-a]diazocin-8-one
• CAS: 881853-39-0
• 化学式: C₁₄H₁₈N₂O₃
• 分子量: 262.309
• InChiKey: BMEUXYQQVWQZIG-WDEREUQCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.44
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  51.54
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (1R,5S)-N-(2-methoxyacetyl)-1,2,3,4,5,6-hexahydro-1,5-methanopyrido[1,2-a]diazocin-8-one 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、101.32 kPa 条件下， 反应 15.0h， 以90%的产率得到(1R,5S)-3-(2-methoxyacetyl)decahydro-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one
  参考文献：
  名称：

  Asymmetric alkylation of diarylmethane derivatives

  摘要：

  Deprotonation-alkylation of prochiral diarylinethane substrates using sec-BuLi and (-)-sparteine has been carried Out in excellent yields and Lip to 94% ee. A variety of enantioselective alkylations, silylations and stannylations have been performed on four different diarylmethanes. Surrogates for (+)-sparteine have also been applied in this Study including a novel surrogate. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.11.044
• 作为产物：
  描述：

  甲氧基乙酰氯 、 cytisine 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以97%的产率得到(1R,5S)-N-(2-methoxyacetyl)-1,2,3,4,5,6-hexahydro-1,5-methanopyrido[1,2-a]diazocin-8-one
  参考文献：
  名称：

  Asymmetric alkylation of diarylmethane derivatives

  摘要：

  Deprotonation-alkylation of prochiral diarylinethane substrates using sec-BuLi and (-)-sparteine has been carried Out in excellent yields and Lip to 94% ee. A variety of enantioselective alkylations, silylations and stannylations have been performed on four different diarylmethanes. Surrogates for (+)-sparteine have also been applied in this Study including a novel surrogate. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.11.044