Hexadeca-trans-2-trans-4-trans-6-trans-8-tetraensaeure | 67214-26-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Hexadeca-trans-2-trans-4-trans-6-trans-8-tetraensaeure
• 英文别名: hexadecatetraenoic acid；(2E,4E,6E,8E)-hexadeca-2,4,6,8-tetraenoic acid
• CAS: 67214-26-0
• 化学式: C₁₆H₂₄O₂
• 分子量: 248.365
• InChiKey: BJNARTXTPVWSGJ-SRGMUBKESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• VINYL MONOMERS HAVING POLYENIC SIDE CHAINS DERIVED FROM HIGHLY UNSATURATED FATTY ACIDS AND DERIVATIVES THEREOF, AND POLYMERS OF SAID MONOMERS
  申请人：NIPPON SUISAN KAISHA, LTD.

  公开号：US20010003128A1

  公开（公告）日：2001-06-07

  Vinyl monomers having polyenic side chains derived from highly unsaturated fatty acids represented by the general formula: R 1 COOH wherein R 1 is a C 19-24 hydrocarbon having 5 or 6 unsaturated bonds, and the derivatives thereof. Vinyl monomers having polyenic side chains derived from highly polyunsaturated fatty acids and the polymers of said monomers can be provided. In addition polymers having double bonds in the side chain into which various functional groups can be introduced can be provided. Useful utilization of fatty acid esters remaining as the residue in distillation of fish oil can be provided.

  具有高度不饱和脂肪酸衍生的多烯侧链的乙烯基单体的一般公式为：R1COOH，其中R1是具有5或6个不饱和键的C19-24碳氢化合物及其衍生物。可以提供由高度多不饱和脂肪酸衍生的多烯侧链的乙烯基单体和其聚合物。此外，可以提供具有侧链中双键的聚合物，其中可以引入各种功能基团。可以提供脂肪酸酯在鱼油蒸馏中残留的有用利用。
• Liposome comprising a novel phosphate as membrane constituent, liposome preparations and cosmetic preparations comprising said phosphate
  申请人：KAO CORPORATION

  公开号：EP0370491A2

  公开（公告）日：1990-05-30

  A novel monophosphate and a novel diphosphate prepared by a phosphatidyl transfer reaction of a phospholipid and an alcohol in the presence of phospholipase D are disclosed. The phosphates can independently or together form small and stable liposomes which can include active components therein. Cosmetic compositions comprising these phosphates or liposomes penetrate well into the hair and the skin, and exhibit long-lasting excellent moisture-retaining, beauty, skin-activation effects.

  本研究公开了一种新型单磷酸盐和一种新型二磷酸盐，它们是在磷脂酶 D 的存在下，通过磷脂和醇的磷脂酰转移反应制备的。这些磷酸盐可单独或共同形成小而稳定的脂质体，其中可包含活性成分。包含这些磷酸盐或脂质体的化妆品组合物可以很好地渗透到头发和皮肤中，并表现出持久的出色保湿、美容和活肤效果。
• Method for preparing fatty acid chlorides
  申请人：Dow Corning Toray Silicone Company, Limited

  公开号：EP0839791A1

  公开（公告）日：1998-05-06

  A method is disclosed for preparing fatty acid chlorides and comprises reacting a silylation product of a fatty acid comprising at least 2 aliphatically unsaturated bonds per molecule and a chlorinating agent.

  本发明公开了一种制备脂肪酸氯化物的方法，该方法包括使一种脂肪酸的硅烷化产物与氯化剂反应，该脂肪酸每个分子至少包含 2 个脂肪族不饱和键。
• DRUG FOR REDUCING SIDE EFFECTS IN RIBAVIRIN INTERFERON COMBINATION THERAPY
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP1595539A1

  公开（公告）日：2005-11-16

  There is provided a drug for reducing side effects, anemia in particular, in combination therapy of chronic hepatitis C with ribavirin and interferon, which contains as the active ingredient at least one member selected from the group consisting of eicosapentaenoic acid (EPA) and pharmaceutically acceptable salts and esters thereof.

  本发明提供了一种药物，用于在利巴韦林和干扰素联合治疗慢性丙型肝炎时减少副作用，尤其是贫血，该药物含有至少一种选自二十碳五烯酸（EPA）及其药学上可接受的盐类和酯类的活性成分。
• DRUG FOR IMPROVING PROGNOSIS FOR SUBARACHNOID HEMORRHAGE
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP1602372A1

  公开（公告）日：2005-12-07

  It is intended to provide a drug for improving prognosis for subarachnoid hemorrhage which contains, as the active ingredient, at least one member selected from the group consisting, of eicosapentaenoic acid (EPA) and pharmaceutically acceptable salts and esters thereof, and a method of improving prognosis for subarachnoid hemorrhage which comprises orally or gastrically administering the above drug.

  本发明旨在提供一种改善蛛网膜下腔出血预后的药物，其活性成分中至少含有一种选自二十碳五烯酸（EPA）及其药学上可接受的盐类和酯类，以及一种改善蛛网膜下腔出血预后的方法，该方法包括口服或胃服上述药物。