6-(4-benzyloxyphenyl)-7-phenyl-3-(2H-tetrazol-5-yl)pyrazolo[1,5-a]pyrimidine | 632362-17-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(4-benzyloxyphenyl)-7-phenyl-3-(2H-tetrazol-5-yl)pyrazolo[1,5-a]pyrimidine
• 英文别名: 7-phenyl-6-(4-phenylmethoxyphenyl)-3-(2H-tetrazol-5-yl)pyrazolo[1,5-a]pyrimidine
• CAS: 632362-17-5
• 化学式: C₂₆H₁₉N₇O
• 分子量: 445.483
• InChiKey: XURMEZUDHPYADJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  93.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  6-(4-Benzyloxyphenyl)-7-phenyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile 在 sodium azide 、 三乙胺盐酸盐 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 6-(4-benzyloxyphenyl)-7-phenyl-3-(2H-tetrazol-5-yl)pyrazolo[1,5-a]pyrimidine
  参考文献：
  名称：

  Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase

  摘要：

  The present paper describes a novel series of HCV RNA polymerase inhibitors based on a pyrazolo[1,5-a]pyrimidine scaffold bearing hydrophobic groups and an acidic functionality. Several compounds were optimized to low nanomolar potencies in a biochemical RdRp assay. SAR trends clearly reveal a stringent preference for a cyclohexyl group as one of the hydrophobes, and improved activities for carboxylic acid derivatives. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.087

文献信息

• US7196111B2
  申请人：——

  公开号：US7196111B2

  公开（公告）日：2007-03-27
• US7449488B2
  申请人：——

  公开号：US7449488B2

  公开（公告）日：2008-11-11
• [EN] PYRAZOLO [1,5-A] PYRIMIDINES AS PROTEIN KINASE INHIBITORS<br/>[FR] PYRAZOLO[1,5-A]PYRIMIDINES SERVANT D'INHIBITEURS DE PROTÉINES KINASES
  申请人：SCHERING CORP

  公开号：WO2007044410A1

  公开（公告）日：2007-04-19

  [EN] In its many embodiments, the present invention provides a novel class of pyrazolo[1 ,5-a] pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions. Formula (I).
  [FR] Dans ses nombreux modes de réalisation, la présente invention concerne une nouvelle classe de composés pyrazolo[1,5-a]pyrimidines servant d'inhibiteurs de protéines kinases et/ou de kinases "points de contrôle" (checkpoint kinases), des procédés de préparation de tels composés, des compositions pharmaceutiques comprenant un ou plusieurs de ces composés, des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés et des procédés de traitement, de prévention, d'inhibition ou d'amélioration d'une ou plusieurs maladies associées aux protéines kinases ou aux checkpoint kinases utilisant de tels composés ou de telles compositions pharmaceutiques. Formule (I).