dimethyl N-acryloyl-L-glutamate | 612850-16-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dimethyl N-acryloyl-L-glutamate
• 英文别名: dimethyl (2S)-2-(prop-2-enoylamino)pentanedioate
• CAS: 612850-16-5
• 化学式: C₁₀H₁₅NO₅
• 分子量: 229.233
• InChiKey: LEMJLDUSTOAIMU-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  dimethyl N-acryloyl-L-glutamate 、 dimethyl N-(but-3-ynoyl)-L-glutamate 生成 dimethyl N-[3-(2-pivaloylamino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)acryloyl]-L-glutamate 、 dimethyl N-[4-(2-pivaloylamino-4-hydroxypyrido[2,3-d]pyrimidin-6-yl)but-3-ynoyl]-L-glutamate
  参考文献：
  名称：

  US4882333

  摘要：

  公开号：

文献信息

• N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
  申请人：THE TRUSTEES OF PRINCETON UNIVERSITY

  公开号：EP0343801A2

  公开（公告）日：1989-11-29

  A compound selected from the group consisting of a glutamic acid derivative of the formula: in which: R¹ is -OH or -NH₂; R² is hydrogen or a carboxy protecting group; R³ is a carbon-carbon bond, alkylene of 1 to 4 car­bon atoms, cyclohexylene, or R⁴ is hydrogen or an amino protecting group; Q is -S- or -O-; R⁵ is hydrogen, chloro or fluoro; and the configuration about the carbon atom designated * is S; and the pharmaceutically acceptable salts thereof. Also disclosed is a method of combatting neoplastic growth in a mammal and a pharmaceutical composition for combatting neoplastic growth in a mammal making use of the above compound.

  本发明涉及一种从以下组合中选择的化合物：其中：R¹为-OH或-NH₂；R²为氢或羧基保护基；R³为碳-碳键，1到4个碳原子的烷基，环己烷基，或R⁴为氢或氨基保护基；Q为-S-或-O-；R⁵为氢，氯或氟；并且指定的碳原子*的构型为S；以及其药学上可接受的盐。本发明还公开了一种在哺乳动物中对抗肿瘤生长的方法和一种制备上述化合物的药物组合物，用于对抗哺乳动物中的肿瘤生长。
• Polymer polyol, and flame retardant polyurethane resin and foam prepared therefrom
  申请人：Mitsui Chemicals, Inc.

  公开号：EP0861861A1

  公开（公告）日：1998-09-02

  A polymer dispersed polyol has a vinyl polymer dispersed in polyol, the vinyl polymer comprising containing 5 to 80 wt% of acrylamide compound (A) represented by the formula (1):         CH2=CR1CONR2R3     (1) wherein R1, R2 and R3 are a hydrogen atom or hydrocarbon group having 1 to 10 carbon atoms, 0 to 70 wt% of one or more monomer (B) selected from acrylonitrile and methacrylonitrile, and 0 to 95 wt% of a vinyl monomer (C) which can copolymerize with (A) and (B), and 95 to 20 wt% of the total amount of (B) and (C); and when (C) is 0 wt%, (A) is the polymer of a vinyl monomer mixture containing an acrylamide derivative represented by the formula (2):         CH2=CR4CONR5R6     (2) wherein R4, R5 and R6 are a hydrogen atom or hydrocarbon group having 1 to 10 carbon atoms, and not simultaneously the hydrogen atom; and said polyol comprising containing 5 to 50 wt% of the vinyl polymer. Flame retardant polyurethane resins and flame retardant polyurethane foams are obtainable from the polymer dispersed polyol.

  一种聚合物分散多元醇具有分散在多元醇中的乙烯基聚合物，该乙烯基聚合物包含 5 至 80 wt%由式（1）表示的丙烯酰胺化合物（A）： CH2=CR1CONR2R3 (1) 其中 R1、R2 和 R3 为氢原子或具有 1 至 10 个碳原子的烃基；0 至 70 wt%的选自丙烯腈和 甲基丙烯腈的一种或多种单体（B）；0 至 95 wt%的可与（A）和（B）共聚的乙烯基单体 （C）；95 至 20 wt%的（B）和（C）总量；当(C)为 0 wt%时，(A)为含有式(2)表示的丙烯酰胺衍生物的乙烯基单体混合物的聚合物： =CR4CONR5R6 (2) 其中 R4、R5 和 R6 为氢原子或具有 1 至 10 个碳原子的烃基，且不同时为氢原子；所述多元醇包括含有 5 至 50 wt%的乙烯基聚合物。阻燃聚氨酯树脂和阻燃聚氨酯泡沫可从聚合物分散多元醇中获得。
• US4882333A
  申请人：——

  公开号：US4882333A

  公开（公告）日：1989-11-21
• US6117937A
  申请人：——

  公开号：US6117937A

  公开（公告）日：2000-09-12