(4S)-2-(2,4-Dihydroxy-3-methylphenyl)-4,5-dihydro-4-thiazolecarboxylic acid | 911714-50-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4S)-2-(2,4-Dihydroxy-3-methylphenyl)-4,5-dihydro-4-thiazolecarboxylic acid
• 英文别名: (4S)-2-(2,4-dihydroxy-3-methylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid
• CAS: 911714-50-6
• 化学式: C₁₁H₁₁NO₄S
• 分子量: 253.28
• InChiKey: JUISXYSHQVXRFN-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Iron binding agents
  申请人：University of Florida

  公开号：US20030083349A1

  公开（公告）日：2003-05-01

  Composition, article of manufacture for and method of treating malaria in a human having an infestation of Plasmodium protozoans are described. The method comprises administering a therapeutically-effective amount of a compound of formula (I) or (IV), i.e. sufficient quantity to reduce the population of Plasmodium. The composition of the invention is a compound of formula (I) or (IV) with a pharmaceutical excipient. The article of manufacture is the composition in combination with labeling for treating malaria. The substituents are detailed in the specification.

  本发明涉及一种用于治疗人类患有疟原虫感染的组合物、制品及方法。该方法包括给予化合物(I)或(IV)的治疗有效量，即足够减少疟原虫数量。本发明的组合物是一种含有药用辅料的化合物(I)或(IV)。制品是该组合物与用于治疗疟疾的标签的组合。取代基详见规范。
• Antimalarial agents
  申请人：UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

  公开号：EP1488791A2

  公开（公告）日：2004-12-22

  Composition, article of manufacture for and method of treating malaria in a human having an infestation of Plasmodium protozoans are described. The method comprises administering a therapeutically effective amount of a compound of formula (I) or (IV), i.e., sufficient quantity to reduce the population of Plasmodium. The composition of the invention is a compound of formula (I) or (IV) with a pharmaceutical excipient. The article of manufacture is the composition in combination with labelling for treating malaria. The substituents are detailed in the specification.

  本发明描述了用于治疗原生动物疟原虫感染的人类疟疾的组合物、制造品和方法。该方法包括施用治疗有效量的式（I）或（IV）化合物，即足以减少疟原虫数量的量。本发明的组合物是含有药用赋形剂的式 (I) 或 (IV) 化合物。制成品是该组合物与用于治疗疟疾的标签相结合。取代基详见说明书。
• DESFERRITHIOCIN POLYETHER ANALOGUES
  申请人：University of Florida Research Foundation, Inc.

  公开号：EP3190106A1

  公开（公告）日：2017-07-12

  Compounds represented by structural formulas described herein, such as Structural Formula (I): are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.

  本文所述结构式（如结构式 (I)）所代表的化合物可用于治疗金属超载、氧化应激、肿瘤和肿瘤前病变等病症。
• ANTIMALARIAL AGENTS
  申请人：UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

  公开号：EP1143951A2

  公开（公告）日：2001-10-17
• Desferrithiocin polyether analogues
  申请人：Bergeron Raymond J.

  公开号：US20080214630A1

  公开（公告）日：2008-09-04

  Compounds represented by structural formulas described herein, such as Structural Formula (I): or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.