6-Aminohexyl carbamate | 1443435-43-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-Aminohexyl carbamate
• CAS: 1443435-43-5
• 化学式: C₇H₁₆N₂O₂
• 分子量: 160.216
• InChiKey: RFGIRNPIHVIBKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  78.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-氨基-1-己醇 、 尿素 反应 3.0h， 生成 6-Aminohexyl carbamate 、 N-(6-hydroxyhexyl)urea
  参考文献：
  名称：

  由甘油或碳酸甘油酯和尿素催化合成羟甲基-2-恶唑烷酮

  摘要：

  恶唑烷酮是通过在γ-Zr磷酸盐作为催化剂的情况下使碳酸甘油酯或甘油与尿素反应而合成的。多元醇或其碳酸盐的转化率取决于温度。低于408 K时，选择性为100％，转化率最高为25％，而提高温度意味着转化率提高，但选择性降低，这使分离过程更加困难。从碳酸甘油酯开始，以大约1：1的摩尔比形成两个异构体6和6'，这是因为尿素会侵蚀羧基CO部分两侧的碳酸酯部分。从甘油中优选形成6 '异构体：6' / 6的比例接近7。形成的恶唑烷酮起模板的作用，因为它们通过与甘油的氢键相互作用。相互作用的强度依赖于6或6'异构体：DFT计算表明，能量为22.6千卡摩尔-1为6 -oxazolidinone和25.7千卡摩尔-1为6' -oxazolidinone。

  DOI：

  10.1002/cssc.201200524

文献信息

• [EN] MODIFIED PROTEINS AND PROTEIN DEGRADERS<br/>[FR] PROTÉINES MODIFIÉES ET AGENTS DE DÉGRADATION DE PROTÉINES
  申请人：CULLGEN SHANGHAI INC

  公开号：WO2021239117A1

  公开（公告）日：2021-12-02

  Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

  本文提供了结合或降解靶蛋白的化合物、药物组合物和方法。本文还提供了具有DNA损伤结合蛋白1（DDB1）结合基团的化合物。其中一些实施例包括连接物。其中一些实施例包括靶蛋白结合基团。本文还提供了配体-DDB1复合物。本文还提供了体内修饰的DDB1蛋白。
• Wear resistant fluoropolymer
  申请人：Xerox Corporation

  公开号：EP1553132A1

  公开（公告）日：2005-07-13

  Disclosed is a fluoroelastomer loaded with an inorganic filler which is coupled to the fluoroelastomer by a titanate, zirconate or aluminate for use as a base layer and/or a release layer on a fuser, transfix, receiver or rheological transfer member in a copy machine. The coupled filler bonds tightly to the fluorocarbon matrix, significantly decreasing the wear rate of the member. These fillers also significantly increase the thermal conductivity of the compound as is often desirable in fusing applications.

  本发明公开了一种含无机填料的氟弹性体，该无机填料通过钛酸盐、锆酸盐或铝酸盐与氟弹性体耦合，可用作复印机中折页机、转页机、接收机或流变传输部件上的底层和/或脱模层。耦合填料能与碳氟化合物基体紧密结合，显著降低构件的磨损率。这些填料还能显著提高化合物的导热性，这在粘合应用中通常是非常理想的。
• LAMINATE, METHOD FOR MANUFACTURING SAME, AND FLUORORUBBER COMPOSITION
  申请人：Daikin Industries, Ltd.

  公开号：EP3069870A1

  公开（公告）日：2016-09-21

  The present invention aims to provide a laminate in which a fluororesin layer and a fluororubber layer are firmly bonded even when the fluororesin layer contains a fluororesin having excellently low fuel permeability. The present invention relates to a laminate including a fluororubber layer (A) and a fluororesin layer (B) stacked on the fluororubber layer (A). The fluororubber layer (A) is a layer formed from a fluororubber composition. The fluororubber composition contains a fluororubber (a1) and a basic multifunctional compound having at least two nitrogen atoms in the molecule with a distance between the nitrogen atoms in the molecule of 5.70 Å or greater. The fluororubber (a1) has an absorption coefficient at 1720 cm-1 1, determined after being brought into contact with triethyl amine, of 0.35 or lower. The fluororesin layer (B) is formed from a fluororesin (b1) having a fuel permeability coefficient of 2.0 g ·mm/m2/dayor lower.

  本发明旨在提供一种层压板，其中的氟树脂层和氟橡胶层即使在氟树脂层含有燃料渗透性极低的氟树脂的情况下也能牢固粘合。本发明涉及一种层压板，包括氟橡胶层（A）和堆叠在氟橡胶层（A）上的氟树脂层（B）。氟橡胶层（A）是由氟橡胶组合物形成的层。氟橡胶组合物包含氟橡胶（a1）和碱性多功能化合物，后者分子中至少有两个氮原子，分子中氮原子间的距离为 5.70 Å 或更大。氟橡胶（a1）在与三乙胺接触后测定的 1720 cm-1 1 处的吸收系数为 0.35 或更低。氟树脂层（B）由燃料渗透系数为 2.0 克-毫米/平方米/天或更低的氟树脂（b1）形成。
• Laminate, method for manufacturing same, and fluororubber composition
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US10421257B2

  公开（公告）日：2019-09-24

  The present invention aims to provide a laminate in which a fluororesin layer and a fluororubber layer are firmly bonded even when the fluororesin layer contains a fluororesin having excellently low fuel permeability. The present invention relates to a laminate including a fluororubber layer (A) and a fluororesin layer (B) stacked on the fluororubber layer (A). The fluororubber layer (A) is a layer formed from a fluororubber composition. The fluororubber composition contains a fluororubber (a1) and a basic multifunctional compound having at least two nitrogen atoms in the molecule with a distance between the nitrogen atoms in the molecule of 5.70 Å or greater. The fluororubber (a1) has an absorption coefficient at 1720 cm−1, determined after being brought into contact with triethyl amine, of 0.35 or lower. The fluororesin layer (B) is formed from a fluororesin (b1) having a fuel permeability coefficient of 2.0 g·mm/m2/day or lower.

  本发明旨在提供一种层压板，其中的氟树脂层和氟橡胶层即使在氟树脂层含有燃料渗透性极低的氟树脂的情况下也能牢固粘合。本发明涉及一种层压板，包括氟橡胶层（A）和堆叠在氟橡胶层（A）上的氟树脂层（B）。氟橡胶层（A）是由氟橡胶组合物形成的层。氟橡胶组合物包含氟橡胶（a1）和碱性多功能化合物，后者分子中至少有两个氮原子，分子中氮原子间的距离为 5.70 Å 或更大。氟橡胶（a1）在与三乙胺接触后测定的 1720 cm-1 处的吸收系数为 0.35 或更低。氟树脂层 (B) 由燃料渗透系数为 2.0 克-毫米/平方米/天或更低的氟树脂 (b1) 构成。
• Imidazole-pyrazole derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US11390604B2

  公开（公告）日：2022-07-19

  The disclosure provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1, RA and R3 to R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

  本公开提供了具有通式 (I) 的新型咪唑吡唑衍生物及其药学上可接受的盐类，其中 X1、RA 和 R3 至 R7 如本文所述： 还提供了包括这些化合物的药物组合物、制造这些化合物的工艺以及将这些化合物用作药物的方法，特别是将这些化合物用作抗生素以治疗或预防细菌感染及其引起的疾病的方法。