2-[2-(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidino]butyl}phenoxy)ethylamino]acetamide | 924279-09-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[2-(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidino]butyl}phenoxy)ethylamino]acetamide
• 英文别名: 3,5-diamino-N-[N'-[4-[4-[2-[(2-amino-2-oxoethyl)amino]ethoxy]phenyl]butyl]carbamimidoyl]-6-chloropyrazine-2-carboxamide
• CAS: 924279-09-4
• 化学式: C₂₀H₂₈ClN₉O₃
• 分子量: 477.954
• InChiKey: AWUDEDKEJJDBFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  33
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  210
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  methyl 3,5-diamino-6-chloropyrazine-2-carbonylcarbamimidothioate hydroiodic acid salt 、 2-{2-[4-(4-aminobutyl)phenoxy]ethylamino}acetamide dihydrochloride 在 N,N-二异丙基乙胺 、 Ammonium hydroxide 作用下， 以 乙醇 、 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 3.5h， 生成 2-[2-(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidino]butyl}phenoxy)ethylamino]acetamide
  参考文献：
  名称：

  New capped pyrazinoylguanidine sodium channel blockers

  摘要：

  本发明涉及钠通道阻滞剂。本发明还包括使用这些创新性钠通道阻滞剂的各种治疗方法。

  公开号：

  US20070032509A1

文献信息

• Capped pyrazinoylguanidine sodium channel blockers
  申请人：Parion Sciences, Inc.

  公开号：US07807834B2

  公开（公告）日：2010-10-05

  The present invention relates to group of pyrazinoylguanidine compounds useful as sodium channel blockers. The compounds may be used to promote promoting hydration of mucosal surfaces.

  本发明涉及一组吡嗪酰胍化合物，可用作钠通道阻滞剂。这些化合物可用于促进黏膜表面的水合作用。
• NEW CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
  申请人：JOHNSON Michael R.

  公开号：US20120220606A1

  公开（公告）日：2012-08-30

  The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

  本发明涉及钠通道阻滞剂。本发明还包括使用这些创新的钠通道阻滞剂的各种治疗方法。
• NEW CAPPED Pyrazinoylguanidine SODIUM CHANNEL BLOCKERS
  申请人：JOHNSON Michael R.

  公开号：US20110003832A1

  公开（公告）日：2011-01-06

  The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

  本发明涉及钠通道阻滞剂。本发明还包括使用这些创新钠通道阻滞剂的各种治疗方法。
• METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES
  申请人：Johnson Michael Ross

  公开号：US20090082287A1

  公开（公告）日：2009-03-26

  The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
• MULTIPLE NEBULIZER SYSTEMS
  申请人：BOUCHER Richard C.

  公开号：US20100074881A1

  公开（公告）日：2010-03-25

  A device for administering two or more therapeutic agents simultaneously, comprising two or more nebulizers and a single connector linking the nebulizers to a nebulizer mouthpiece. Also provided is a method of administering two or more therapeutic agents simultaneously, comprising administering the therapeutic agents simultaneously with the device of the present invention to a subject in need thereof.