ω-bromo(N,N-dioctadecyl)hexanamide | 159684-90-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ω-bromo(N,N-dioctadecyl)hexanamide
• CAS: 159684-90-9
• 化学式: C₄₂H₈₄BrNO
• 分子量: 699.039
• InChiKey: GLGMUDNTADIRNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.29
• 重原子数：
  45.0
• 可旋转键数：
  39.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.98
• 拓扑面积：
  20.31
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  ω-bromo(N,N-dioctadecyl)hexanamide 在 肼 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 20.0h， 生成
  参考文献：
  名称：

  A Kinetic Study of Concanavalin A Binding to Glycolipid Monolayers by Using a Quartz-Crystal Microbalance

  摘要：

  Specific binding and dissociation processes of concanavalin A (Con A) to a mixed monolayer containing synthetic glycolipids at the air-water interface were observed from frequency changes of a quartz-crystal microbalance (QCM) that was attached horizontally on the monolayer from the air phase. Binding constants (k(1)), dissociation rate constants (k(-1)), and binding amount (Delta m) could be obtained from time courses of the frequency decrease (mass increase) of the QCM. Con A showed the specific binding to 2C(18)-mal lipids having a glucopyranosyl head group but not ?Cls-lac lipids having a galactopyranosyl head group in the matrix of phosphoethanolamine lipids (2C(18)PE). The maximum binding amount (Delta m(max)) was independent of the mole fraction of the 2C(18)-mal, but on the contrary, binding (k(1)), dissociation rate (k(-1)), and association constants (K-a = k(1)/k(-1)) were affected largely by the content of the 2C(18)-mal in the monolayer.

  DOI：

  10.1021/ja00104a001
• 作为产物：
  描述：

  6-溴己酰氯 、 双十八烷基胺 在 三乙胺 作用下， 以 氯仿 为溶剂， 以76%的产率得到ω-bromo(N,N-dioctadecyl)hexanamide
  参考文献：
  名称：

  A Kinetic Study of Concanavalin A Binding to Glycolipid Monolayers by Using a Quartz-Crystal Microbalance

  摘要：

  Specific binding and dissociation processes of concanavalin A (Con A) to a mixed monolayer containing synthetic glycolipids at the air-water interface were observed from frequency changes of a quartz-crystal microbalance (QCM) that was attached horizontally on the monolayer from the air phase. Binding constants (k(1)), dissociation rate constants (k(-1)), and binding amount (Delta m) could be obtained from time courses of the frequency decrease (mass increase) of the QCM. Con A showed the specific binding to 2C(18)-mal lipids having a glucopyranosyl head group but not ?Cls-lac lipids having a galactopyranosyl head group in the matrix of phosphoethanolamine lipids (2C(18)PE). The maximum binding amount (Delta m(max)) was independent of the mole fraction of the 2C(18)-mal, but on the contrary, binding (k(1)), dissociation rate (k(-1)), and association constants (K-a = k(1)/k(-1)) were affected largely by the content of the 2C(18)-mal in the monolayer.

  DOI：

  10.1021/ja00104a001