6,8-dimethyl-10H-pyrano<2',3':4,5>benzofuro<3,2-c>pyridin-10-one | 144822-81-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 6,8-dimethyl-10H-pyrano<2',3':4,5>benzofuro<3,2-c>pyridin-10-one
• 英文别名: 6,9-dimethyl-3,11-dioxa-15-azatetracyclo[8.7.0.02,7.012,17]heptadeca-1(10),2(7),5,8,12(17),13,15-heptaen-4-one
• CAS: 144822-81-1
• 化学式: C₁₆H₁₁NO₃
• 分子量: 265.268
• InChiKey: ZYABMUOTERLUJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6,8-dimethyl-1,2,3,4-tetrahydro-10H-pyrano<2',3':4,5>benzofuro<3,2-c>pyridin-10-one hydrochloride 在 palladium on activated charcoal 作用下， 以 萘烷 为溶剂， 反应 1.0h， 以37.8%的产率得到6,8-dimethyl-10H-pyrano<2',3':4,5>benzofuro<3,2-c>pyridin-10-one
  参考文献：
  名称：

  Synthesis of 11H-Furo[3',2':7,8]benzopyrano[3,4-c]pyridin-11-one and 6,8-Dimethyl-10H-pyrano[2',3':4,5]benzofuro[3,2-c]pyridin-10-one (Pyridoangelicins)

  摘要：

  11H-Furo[3',2' : 7,8]benzopyrano[3,4-c]pyridin-11-one (3) was synthesized from 1-benzyl-3-ethoxycarbonylpiperidin-4-one and 2,3-dihydro-4-hydroxybenzofuran (5) by a von Pechmann reaction and subsequent aromatization of the hexahydro derivative (6). 6,8-Dimethyl-10H-pyrano[2',3' : 4,5] benzofuro-[3,2-c]pyridin-10-one (4a) was obtained by dehydrogenation of the tetrahydro derivative (10b). This compound was prepared from piperidinone-O-(4,6-dimethylcoumarin-7-yl) oxime (9b) using acid catalyzed Fischer indole-like reaction. Are also reported and compared the results of the reactions of piperidinone-O-(coumarin-7-yl) oxime (9d) and the corresponding 5-methyl (9e) derivative, in which the rearrangement occurs at both the 8 and the 6 positions.

  DOI：

  10.3987/com-92-6021