9α,15α-Dihydroxyprostansaeure | 20592-19-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9α,15α-Dihydroxyprostansaeure
• 英文别名: 7-[(1R,2S,5S)-2-hydroxy-5-[(3S)-3-hydroxyoctyl]cyclopentyl]heptanoic acid
• CAS: 20592-19-2
• 化学式: C₂₀H₃₈O₄
• 分子量: 342.519
• InChiKey: IXMRVDPNBMQSIW-OKYOBFRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] POLYMER CONJUGATED PROSTAGLANDIN ANALOGUES<br/>[FR] ANALOGUES DE PROSTAGLANDINE CONJUGUÉS À UN POLYMÈRE
  申请人：POLYACTIVA PTY LTD

  公开号：WO2012139164A1

  公开（公告）日：2012-10-18

  The present invention relates in general to polymer-drug conjugates. In particular, the invention relates to polymer-drug conjugates wherein the conjugated drugs are selected from prostaglandins and substituted prostaglandins, to a method of delivering such prostaglandin drugs to a subject, to a sustained drug delivery system comprising the polymer-drug conjugates, to a method of preparing the polymer-drug conjugates, and to an implant comprising the polymer-drug conjugates. The polymer-drug conjugates may be useful for delivering prostaglandins and substituted prostaglandins for the treatment of glaucoma.