Acetamide, N-[2-(acetylamino)ethyl]-2-iodo- | 1341977-28-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetamide, N-[2-(acetylamino)ethyl]-2-iodo-
• 英文别名: N-(2-acetamidoethyl)-2-iodoacetamide
• CAS: 1341977-28-3
• 化学式: C₆H₁₁IN₂O₂
• 分子量: 270.07
• InChiKey: BABNKHJKBOZHHX-UHFFFAOYSA-N

物化性质

• 沸点：
  495.8±30.0 °C(Predicted)
• 密度：
  1.706±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• MARKER DYES FOR UV AND SHORT WAVE EXCITATION WITH HIGH STOKES SHIFT BASED ON BENZOXAZOLES
  申请人：Dyomics GmbH

  公开号：US20150175591A1

  公开（公告）日：2015-06-25

  The invention concerns compounds based on benzoxazoles wherein selected substituents are each a reactive group A bound via a linker L and adapted to covalently bond a compound of the invention to a to-be-marked molecule K, wherein A is an amine, hydroxy or phosphoramidite function, a carboxylic acid, an alkyl or active ester derived therefrom; a carboxylic acid hydrazide; or a carboxylic acid amide where K is a covalently bound component selected from the group haptenes−, proteins (antibodies), low molecular weight drug compounds, peptides, nucleotides, nucleosides, DNA oligomers, polymers, and t is from 1 to 10, and L is a linker selected from a group featuring —(CH 2 ) s —, —[(CH 2 ) m —O] p —(CH 2 ) m —, —NR10-(CH 2 ) s —, —O—(CH 2 ) s —, —S—(CH 2 ) s —, —NR10-C(O)—(CH 2 ) s —, —NR10-C(O)—O—(CH 2 ) s —, —NR10-C(O)—NR11-(CH 2 ) s — or —SO 2 —NR10-(CH 2 ) s —, wherein R10 and R11 are each independently hydrogen, alkyl and alkoxy-alkyl (—[(CH 2 ) m —O] p —CH 3 ), ω-sulfoalkyl (—(CH 2 ) r —SO 3 ), m represents the numbers of 2-5, p, r and s each independently represent the number of 1-10.

  该发明涉及基于苯并噁唑的化合物，其中所选取的取代基分别是通过连接基L结合的反应性基团A，并适用于以共价键将该发明的化合物结合到待标记的分子K，其中A是胺基、羟基或磷酰胺基、羧酸、由此衍生的烷基或活性酯；羧酸肼；或羧酸酰胺，其中K是从半抗原、蛋白质（抗体）、低分子量药物化合物、肽、核苷酸、核苷、DNA寡聚物、聚合物中选择的共价结合组分，t为1至10，L是从特征为—(CH2)s—、—[( )m—O]p—( )m—、—NR10-( )s—、—O—( )s—、—S—( )s—、—NR10-C(O)—( )s—、—NR10-C(O)—O—( )s—、—NR10-C(O)—NR11-( )s—或—SO2—NR10-( )s—的一组中选择的连接基，其中R10和R11各自独立地是氢、烷基和烷氧基烷基（—[( )m—O]p—CH3）、ω-磺酰基烷基（—( )r—SO3），m代表2-5的数字，p、r和s各自独立地代表1-10的数字。
• [EN] HOMOALLYLAMINES AS FORMALDEHYDE-RESPONSIVE TRIGGERS<br/>[FR] HOMOALLYLAMINES EN TANT QUE DÉCLENCHEURS SENSIBLES AU FORMALDÉHYDE
  申请人：UNIV CALIFORNIA

  公开号：WO2017034927A1

  公开（公告）日：2017-03-02

  Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic or fluorogenic probes, such as a probe including a quencher in energy-receiving proximity to a fluroophore. Also provided are methods of using the probes for sensitive and bioorthogonal detection of FA in a sample. Aspects of the methods include selectively reacting the probe with the formaldehyde in the sample to a release (e.g., via a 2-aza- Cope rearrangement) a reporter group comprising a detectable moiety. Aspects of the methods detecting formaldehyde in a cell, tissue, organ or fluid in a subject. Also provided are compositions and kits including the subject probes that find use in practicing various embodiments of the subject methods.

  提供了一种包括与可检测基团连接的全丙烯胺诱导基团的甲醛（FA）探针。探针的方面包括发光或荧光探针，例如包括在能量接收距离内与荧光团结合的猝灭剂的探针。还提供了使用这些探针在样本中对FA进行敏感和生物正交检测的方法。方法的方面包括选择性地将探针与样本中的甲醛反应，以释放（例如，通过2-aza-Cope重排）包含可检测基团的报告基团。方法的方面包括检测主体中的细胞、组织、器官或液体中的甲醛。还提供了包括这些主体探针的组合物和试剂盒，用于实施主体方法的各种实施方式。
• Markerfarbstoffe für UV- und kurzwellige Anregung mit hohem Stokes Shift auf der Basis von Benzoxazolen
  申请人：Dyomics GmbH

  公开号：EP2886542B1

  公开（公告）日：2018-04-18
• MASS LABELS
  申请人：ELECTROPHORETICS LIMITED

  公开号：US20170045526A1

  公开（公告）日：2017-02-16

  The present invention provides a method for labelling one or more analytes in a sample, the method comprising: a) contacting the sample with one or more bifunctional linker reagents having the general formula Re 1 -L 1 -Re 2 , wherein Re 1 is a first reactive group, L 1 is a linker moiety and Re 2 is a second reactive group, wherein Re 1 reacts with an analyte to form a modified analyte; and b) contacting the sample with one or more mass labels, wherein Re 2 of the bifunctional linker attached to the analyte reacts with a mass label to form a labelled analyte, wherein each mass label is relatable to an analyte by mass spectrometry.
• US9453010B2
  申请人：——

  公开号：US9453010B2

  公开（公告）日：2016-09-27