Cyclohexanecarboxylic acid [2-(2-amino-benzoimidazol-1-yl)-eth-yl]-methyl-amide | 945022-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: Cyclohexanecarboxylic acid [2-(2-amino-benzoimidazol-1-yl)-eth-yl]-methyl-amide
• CAS: 945022-75-3
• 化学式: C₁₇H₂₄N₄O
• 分子量: 300.404
• InChiKey: SVOAXWUCEWPNDP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  Cyclohexanecarboxylic acid [2-(2-amino-benzoimidazol-1-yl)-eth-yl]-methyl-amide 、 2'-溴-4-氯苯乙酮 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-[2-[3-[2-(4-chlorophenyl)-2-oxoethyl]-2-iminobenzimidazol-1-yl]ethyl]-N-methylcyclohexanecarboxamide
  参考文献：
  名称：

  Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3

  摘要：

  Modi. cation of a 2-iminobenzimidazole series derived from an HTS hit resulted in compounds with improved in-vitro species selectivity. Incorporation of an 8-quinoline amide and conformational rigidification of an aliphatic tether furnished potent compounds suitable for further lead optimization. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.049
• 作为产物：
  描述：

  C₁₀H₁₄N₄ 、 环己甲酰氯 在 TEA 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 Cyclohexanecarboxylic acid [2-(2-amino-benzoimidazol-1-yl)-eth-yl]-methyl-amide
  参考文献：
  名称：

  Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3

  摘要：

  Modi. cation of a 2-iminobenzimidazole series derived from an HTS hit resulted in compounds with improved in-vitro species selectivity. Incorporation of an 8-quinoline amide and conformational rigidification of an aliphatic tether furnished potent compounds suitable for further lead optimization. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.049