1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-((S)-3-hydroxy-1-trimethylsilanyloxy-propyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione | 244035-22-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-((S)-3-hydroxy-1-trimethylsilanyloxy-propyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
• 英文别名: 1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[(1S)-3-hydroxy-1-trimethylsilyloxypropyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 244035-22-1
• 化学式: C₂₁H₄₀N₂O₆Si₂
• 分子量: 472.729
• InChiKey: FGVBAFVXCVFLKL-WNRNVDISSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.13
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  97.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-((S)-3-hydroxy-1-trimethylsilanyloxy-propyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 在 吡啶 、 对甲苯磺酸 作用下， 以 甲醇 、 氯仿 为溶剂， 生成 TBDMS(-3)[Tos(-7)]2,6-deoxy-L-lyxHeptf(a)-thymin-1-yl
  参考文献：
  名称：

  5′-C-Tosyloxyalkylnucleosides. Models for Oligonucleotide Coupling with Nucleophiles

  摘要：

  5'-C-substituted nucleosides with an hydroxyalkyl chain are synthesized. The stereochemistry of the new stereogenic center is defined. After introduction of a tosyl group, dimer models are prepared to evaluate the conjugation with amines used as nucleophiles.

  DOI：

  10.1080/07328319908044777
• 作为产物：
  描述：

  (S)-3-[(2S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-trimethylsilanyloxy-propionic acid methyl ester 在 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 生成 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-((S)-3-hydroxy-1-trimethylsilanyloxy-propyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  5′-C-Tosyloxyalkylnucleosides. Models for Oligonucleotide Coupling with Nucleophiles

  摘要：

  5'-C-substituted nucleosides with an hydroxyalkyl chain are synthesized. The stereochemistry of the new stereogenic center is defined. After introduction of a tosyl group, dimer models are prepared to evaluate the conjugation with amines used as nucleophiles.

  DOI：

  10.1080/07328319908044777