1-acetyl-3-(2-benzyloxy-phenyl)-5-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-4-ol | 37071-97-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-acetyl-3-(2-benzyloxy-phenyl)-5-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-4-ol
• 英文别名: 1-[4-Hydroxy-3-(4-methoxyphenyl)-5-(2-phenylmethoxyphenyl)-3,4-dihydropyrazol-2-yl]ethanone
• CAS: 37071-97-9
• 化学式: C₂₅H₂₄N₂O₄
• 分子量: 416.477
• InChiKey: QWMJFYVLESJQAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• METHODS AND COMPOSITIONS RELATING TO STEROID HORMONE RECEPTOR-DEPENDENT CANCERS
  申请人：Wayne State University

  公开号：US20200155501A1

  公开（公告）日：2020-05-21

  There is a continuing need for methods and compositions relating to hormone-receptor-dependent cancers, including pharmaceutical compositions including one or more compounds having activity against steroid hormone-receptor-dependent cancer and methods of treatment of a steroid hormone-receptor-dependent cancer in a subject using said pharmaceutical compositions. ELK1 Is a steroid hormone receptor tethering, protein that is implicated in hormone receptor dependent cancers. Compositions and methods according to aspects of the present invention inhibit the association of steroid hormone receptors with ELKL providing activity against steroid hormone-receptor-dependent cancer. Such compositions are provided including any one or more of: chemical compound structures I, II, III, IV, V, Vi, VII, one or more derivatives, and/or one or more: pharmaceutically acceptable esters and/or one or more pharmaceutically acceptable salts, of any thereof, wherein a pharmaceutically acceptable carrier may be included in the compositions.