4-[(2-hydroxyethyl)(methyl)amino]-5-methyl-2-(4-methylphenyl)thieno[2,3-d]pyrimidine-6-carbonitrile | 731856-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 4-[(2-hydroxyethyl)(methyl)amino]-5-methyl-2-(4-methylphenyl)thieno[2,3-d]pyrimidine-6-carbonitrile
• 英文别名: 4-[2-Hydroxyethyl(methyl)amino]-5-methyl-2-(4-methylphenyl)thieno[2,3-d]pyrimidine-6-carbonitrile
• CAS: 731856-12-5
• 化学式: C₁₈H₁₈N₄OS
• 分子量: 338.433
• InChiKey: IYGZIWBURBXTSA-UHFFFAOYSA-N

物化性质

• 密度：
  1.33±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] 4-AMINOTHIENO[2,3-d]PYRIMIDINE-6-CARBONITRILE DERIVATIVES AS PDE7 INHIBITORS<br/>[FR] DERIVES DE 4-AMINOTHIENO[2,3-D]PYRIMIDINE-6-CARBONITRILE UTILISES COMME INHIBITEURS DE PDE7
  申请人：ALMIRALL PRODESFARMA SA

  公开号：WO2004065391A1

  公开（公告）日：2004-08-05

  New 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives having the chemical structure of general formula (I), and pharmaceutically acceptable salts thereof are disclosed as well as processes for their preparation and to pharmaceutical compositions containing them and their use in the treatment, prevention or suppression of pathological conditions, diseases and disorders susceptible of being improved by inhibition of PDE7.

  揭示了具有通用式(I)的化学结构的新4-氨基噻吩[2,3-d]嘧啶-6-碳腈衍生物，以及其药学上可接受的盐，以及它们的制备过程、含有它们的药物组合物以及它们在治疗、预防或抑制通过抑制PDE7可改善的病理状况、疾病和疾病的用途。
• 4-Aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives as pde7 inhibitors
  申请人：Terricabras Belart Emma

  公开号：US20060229306A1

  公开（公告）日：2006-10-12

  New 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives having the chemical structure of general formula (I), and pharmaceutically acceptable salts thereof are disclosed, as well as processes for their preparation and to pharmaceutical compositions containing them and their use in the treatment, prevention or suppression of pathological conditions, diseases and disorders susceptible of being improved by inhibition of PDE7.

  本发明公开了具有一般式(I)的化学结构的新4-氨基噻吩[2,3-d]嘧啶-6-腈衍生物及其药学上可接受的盐，以及制备它们的方法和包含它们的制药组合物，以及它们在治疗、预防或抑制通过抑制PDE7改善的病理状况、疾病和障碍中的使用。
• 4-AMINOTHIENO [2,3-d] PYRIMIDINE-6-CARBONITRILE DERIVATIVES AS PDE7 INHIBITORS
  申请人：Laboratorios Almirall, S.A.

  公开号：EP1590352B1

  公开（公告）日：2007-06-27
• US7662814B2
  申请人：——

  公开号：US7662814B2

  公开（公告）日：2010-02-16