4-甲酰氨基苯磺酰胺 | 829-72-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-甲酰氨基苯磺酰胺
• 英文名称: N-formyl-sulfanilic acid amide
• 英文别名: N-Formyl-sulfanilsaeure-amid；Ameisensaeure-(4-sulfamoyl-anilid)；4-Formamino-benzolsulfonsaeureamid；N⁴-Formyl-sulfanilamid；N⁴-Formylsulfanilamide；N-(4-sulfamoylphenyl)formamide
• CAS: 829-72-1
• 化学式: C₇H₈N₂O₃S
• 分子量: 200.218
• InChiKey: KKKIBYJCYMQYMU-UHFFFAOYSA-N

物化性质

• 熔点：
  167-170 °C
• 沸点：
  483.1±47.0 °C(Predicted)
• 密度：
  1.481±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  4-甲酰氨基苯磺酰胺 在 sodium hydroxide 作用下， 生成 磺胺
  参考文献：
  名称：

  Bras, Zhurnal Prikladnoi Khimii, 1944, vol. 17, p. 508,510, 512

  摘要：

  DOI：
• 作为产物：
  描述：

  N-苯基甲酰胺 在 ammonium hydroxide 、 chlorosulphuric acid 作用下， 生成 4-甲酰氨基苯磺酰胺
  参考文献：
  名称：

  Bras; Al'bizkaja; Schkral', Zhurnal Prikladnoi Khimii, 1944, vol. 17, p. 502,504

  摘要：

  DOI：

文献信息

• [EN] SULFANYLAMIDE DERIVATIVES, USES THEREOF AND COMPOSITIONS COMPRISING THEM<br/>[FR] DÉRIVÉS DE SULFANYLAMIDE, LEURS UTILISATIONS ET COMPOSITIONS LES CONTENANT
  申请人：YISSUM RES DEV CO

  公开号：WO2011033518A1

  公开（公告）日：2011-03-24

  The present invention concerns a family of sulfanilamide derivatives of formula (I) as anticonvulsant agents, where R1 is selected from optionally substituted C4-C9 alkyl, optionally substituted C6-C10 aryl, optionally substituted C6-C10 alkylenearyl and optionally substituted C5-C10 heteroaryl; R2 is selected from -H and optionally substituted C1-C6 alkyl; each of R3 and R4, independently of each other, is selected from -H, optionally substituted C1-C6 alkyl, optionally substituted C6-C10 aryl and optionally substituted C5-C10 heteroaryl; n is 0, 1, 2, 3 or 4. The derivatives have been prepared and their anticonvulsant profile was evaluated for the control of epileptic seizures.

  本发明涉及一类磺胺基苯甲酰胺衍生物，其化学式为(I)，作为抗癫痫药物，其中R1选自可选取的取代的C4-C9烷基、可选取的取代的C6-C10芳基、可选取的取代的C6-C10烷基芳基和可选取的取代的C5-C10杂环芳基；R2选自-H和可选取的取代的C1-C6烷基；R3和R4中的每一个，独立地选自-H、可选取的取代的C1-C6烷基、可选取的取代的C6-C10芳基和可选取的取代的C5-C10杂环芳基；n为0、1、2、3或4。这些衍生物已经制备，并评估了它们的抗癫痫特性以控制癫痫发作。
• Novel coumarin-amide derivatives and its preparation, said drug composition and its use
  申请人：Xu Shiping

  公开号：US20060148834A1

  公开（公告）日：2006-07-06

  The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas.

  本发明涉及新型香豆素衍生物，它们的羧酰胺，包含它们的制药组合物以及它们作为肾脏保护药物、治疗高血压、心脑血管疾病、非胰岛素依赖性糖尿病、肿瘤、癌前病变和水肿的用途。
• SYNTHESIS OF SUBSTITUTED PYRAZOLINE CARBOXAMIDINE DERIVATIVES
  申请人：van Loevezijn Arnold

  公开号：US20130060041A1

  公开（公告）日：2013-03-07

  This invention relates to organic chemistry, in particular to processes for the preparation of pyrazoline carboxamidine derivatives of formula (I), known as potent 5-HT6 antagonists. The invention also relates to novel intermediates of these compounds. wherein the symbols have the meanings given in the description.

  本发明涉及有机化学，特别是关于制备式(I)的吡唑啉羧酰胺衍生物的过程，这些衍生物被称为有效的5-HT6受体拮抗剂。本发明还涉及这些化合物的新型中间体。其中符号的含义如描述所示。
• THE NOVEL COUMARIN-AMIDE DERIVATIVES AND ITS PREPARATION, SAID DRUG COMPOSITION AND ITS USE
  申请人：THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP1570846A1

  公开（公告）日：2005-09-07

  The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas.

  本发明涉及新型香豆素衍生物、其羧酰胺、含有它们的药物组合物及其作为保护肾脏、治疗高血压、心脑血管疾病、非胰岛素依赖型糖尿病、肿瘤、癌前病变和水肿药物的用途。
• Novel 2H-chromen-2-one-3-carboxamides for medical uses
  申请人：THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP2295053A1

  公开（公告）日：2011-03-16

  The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them, and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas. Claimed are compounds of general formula (I): wherein R3 is selected from the group consisting , CONHR9 R4 is selected from the group consisting of hydrogen, CONHR10, R5 is selected from the group consisting of H, and C1-C4 alkyl; R6 is selected from the group consisting of H, C1-C12 alkyl, halogen, NO2, and CONHR13, R8 is selected from the group consisting of H, C1-C4 alkyl or alkoxyl, NO2. The other variables are as defined in claims.

  本发明涉及新型香豆素衍生物、它们的羧酰胺、含有它们的药物组合物，以及它们作为保护肾脏的药物、治疗高血压、心脑血管疾病、非胰岛素依赖型糖尿病、肿瘤、癌前病变和水肿的药物的用途。 所要求的是通式(I)化合物： 其中 R3 选自以下组成的组 CONHR9 R4 选自由氢、CONHR10 组成的组 R5 选自由 H 和 C1-C4 烷基组成的组； R6 选自由 H、C1-C12 烷基、卤素、NO2 和 CONHR13 组成的组、 R8选自由H、C1-C4烷基或烷氧基、NO2组成的组。 其他变量如权利要求中所定义。