2,6-bis[N-(3-aminopropyl)aminomethyl]pyridine | 118230-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-bis[N-(3-aminopropyl)aminomethyl]pyridine
• 英文别名: N'-[[6-[(3-aminopropylamino)methyl]pyridin-2-yl]methyl]propane-1,3-diamine
• CAS: 118230-14-1
• 化学式: C₁₃H₂₅N₅
• 分子量: 251.375
• InChiKey: MLCOQALRIWTHPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  89
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,1-双(二乙氧基磷酰基)乙烯 、 2,6-bis[N-(3-aminopropyl)aminomethyl]pyridine 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation

  摘要：

  A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinity for the uranyl ion and were selected for evaluation of their in vivo uranyl-removal efficacy. Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver. Among the other ligands, the most potent was the dipodal bisphosphonate 3C which reduced the retention of uranyl and increased its excretion by around 10% of the injected metal. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.01.018
• 作为产物：
  描述：

  N-[3-({6-[(3-Acetylamino-propylamino)-methyl]-pyridin-2-ylmethyl}-amino)-propyl]-acetamide 在 盐酸 、 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 2,6-bis[N-(3-aminopropyl)aminomethyl]pyridine
  参考文献：
  名称：

  Brooker, Sally; Simpson, Timothy J., Journal of the Chemical Society, Dalton Transactions, 1998, # 7, p. 1151 - 1154

  摘要：

  DOI：

文献信息

• Synthesis and Structure of a Tetracopper(II) Complex of a Pyrrole-Containing Unsymmetrical Binucleating Ligand: [Cu2L(NCS)2]2
  作者：S. Brooker、B. M. Carter

  DOI：10.1107/s0108270195001363

  日期：1995.8.15

  The unsymmetrical binucleating ligand H(2)L (L = C23H29N7) was formed in situ from the condensation of two equivalents of 2-pyrrolecarboxaldehyde with one equivalent of 2,6-bis[N-(3-aminopropyl)aminomethyl]-pyridine. Subsequent addition of two equivalents of copper acetate followed by two equivalents of sodium thiocyanate yielded [Cu(2)L(NCS)(2)](2), bis[7,7'-pyridine-2,6-diylbis(2,6-diazahept-1-en-1-yl)di-2-pyrrolaro]bis(thiocyanato)dicopper(II)}. The complex exists as a dimer of dicopper(II) units held together by two 1,3-thiocyanate ion bridges.
• US5017274A
  申请人：——

  公开号：US5017274A

  公开（公告）日：1991-05-21
• [EN] POLYALKYLAMINE COMPLEXES FOR LIGAND EXTRACTION AND GENERATION
  申请人：AQUANAUTICS CORPORATION

  公开号：WO1988006641A1

  公开（公告）日：1988-09-07

  (EN) Methods and apparatus for the extraction of ligand such as molecular oxygen from a first fluid environment (5) and for release of a ligand such as molecular oxygen, as well as ligand carrier compounds (6a) therefor comprising linear pentadentate polyalkylamines and transition metal ions. The carrier compounds have general formula (I), where M is an electrochemically active transition metal ion; R1 and R2 are each organic groups including a nitrogen coordinated to M; m, n, o, and p are each 1, 2, 3, or 4; and X is selected from the group consisting of 2,6-pyridyl, 2,6-piperidyl, 2,5-pyrrolyl, 2,4-imidazolyl, substituted heterocyclic amines, -O-, -S-, -P-, and -N-R3 where R is hydrogen, lower alkyl or aralkyl. By providing an electrocatalyst capable of rapid electron transfer and having an electropotential less than that of the carrier compound, low energy electron transfer between the carrier compounds and the electrodes (8, 10) of the electrochemical cell is achieved. The use of electrodes having catalytically active surface sites leads to efficient electron transfer between the carrier compounds and the electrodes of the electrochemical cell, resulting in lower energy consumption and/or increased oxygen output.(FR) Procédé et appareil destinés à l'extraction d'un ligand tel que de l'oxygène moléculaire, à partir d'un premier environnement fluide (5), et à la libération d'un ligand tel que de l'oxygène moléculaire, ainsi que de composés porteurs de ligand (6a) comprenant des polyalkylamines de pentadentate linéaires et des ions de métal de transition. Les composés porteurs ont la formule générale (I) dans laquelle M représente un ion de métal de transition actif électrochimiquement; R1 et R2 représentent chacun des groupes organiques incluant un azote coordonné à M; m, n, o et p représentent chacun 1, 2, 3, ou 4; et X est sélectioné à partir du groupe se composant de 2,6-pyridyle, 2,6-pipéridyle, 2,5-pyrrolyle, 2,4-imidazolyle, des amines hétérocycliques substituées, -O-, -S-, -P-, et -N-R3 dans lesquels R représente hydrogène, un aralkyle ou un alkyle inférieur. En utilisant un électrocatalyseur pouvant transférer rapidement des électrons et ayant un électropotentiel inférieur à celui du composé porteur, on obtient un transfert d'électrons à faible énergie entre les composés porteurs et les électrodes (8, 10) de la cellule électrochimique. L'utilisation d'électrodes ayant des emplacements de surface catalytiquement actifs conduit à un transfert d'électrons efficace entre les composés porteurs et les électrodes de la cellule électrochimique, aboutissant à une diminution de la consommation d'énergie et/ou une augmentation de la production d'oxygène.
• Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation
  作者：Marcin Sawicki、Delphine Lecerclé、Gérard Grillon、Béatrice Le Gall、Anne-Laure Sérandour、Jean-Luc Poncy、Théodorine Bailly、Ramon Burgada、Marc Lecouvey、Vincent Challeix、Antoine Leydier、Stephane Pellet-Rostaing、Eric Ansoborlo、Frédéric Taran

  DOI：10.1016/j.ejmech.2008.01.018

  日期：2008.12

  A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinity for the uranyl ion and were selected for evaluation of their in vivo uranyl-removal efficacy. Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver. Among the other ligands, the most potent was the dipodal bisphosphonate 3C which reduced the retention of uranyl and increased its excretion by around 10% of the injected metal. (C) 2008 Elsevier Masson SAS. All rights reserved.
• Brooker, Sally; Simpson, Timothy J., Journal of the Chemical Society, Dalton Transactions, 1998, # 7, p. 1151 - 1154
  作者：Brooker, Sally、Simpson, Timothy J.

  DOI：——

  日期：——