2-(4-butyl-2,3-dioxopiperazin-1-yl)-4-phenylbutanoic acid | 902146-89-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(4-butyl-2,3-dioxopiperazin-1-yl)-4-phenylbutanoic acid
• CAS: 902146-89-8
• 化学式: C₁₈H₂₄N₂O₄
• 分子量: 332.4
• InChiKey: WXUXBRXOWPFXFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  77.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Aminomethyl Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
  申请人：Coburn Craig A.

  公开号：US20080153846A1

  公开（公告）日：2008-06-26

  The present invention is directed to aminomethyl compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及氨甲基化合物，它们是β-分泌酶酶的抑制剂，并且在β-分泌酶酶参与的疾病的治疗中非常有用，例如阿尔茨海默病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在β-分泌酶酶参与的这些疾病的治疗中的用途。
• AMINOMETHYL BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Merck & Co., Inc.

  公开号：EP1855679A2

  公开（公告）日：2007-11-21
• US7820674B2
  申请人：——

  公开号：US7820674B2

  公开（公告）日：2010-10-26
• [EN] AMINOMETHYL BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] INHIBITEURS DE LA $G(B)-SECRETASE D'AMINOMETHYLE DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK & CO INC

  公开号：WO2006078576A2

  公开（公告）日：2006-07-27

  [EN] The present invention is directed to aminomethyl compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
  [FR] La présente invention concerne des composés d'aminométhyle qui sont des inhibiteurs de l'enzyme ß-secrétase et qui sont utilisés dans le traitement de maladies, dans lesquelles est impliquée ladite enzyme ß-secrétase, telles que la maladie d'Alzheimer. Cette invention a aussi pour objet des compositions pharmaceutiques renfermant ces composés et l'utilisation desdits composés et compositions dans le traitement de maladies, dans lesquelles est impliquée l'enzyme ß-secrétase.