N-(2,6-diisopropylphenyl)-N'-(2-methylphenyl)formamidine | 1025068-43-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,6-diisopropylphenyl)-N'-(2-methylphenyl)formamidine
• 英文别名: N'-[2,6-di(propan-2-yl)phenyl]-N-(2-methylphenyl)methanimidamide
• CAS: 1025068-43-2
• 化学式: C₂₀H₂₆N₂
• 分子量: 294.44
• InChiKey: UXSAZLFQRHYWGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(2,6-diisopropylphenyl)-N'-(2-methylphenyl)formamidine 在 sodium tetrahydroborate 、 potassium carbonate 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 丙酮 为溶剂， 反应 0.08h， 生成
  参考文献：
  名称：

  Tailor-made synthesis of various backbone-substituted imidazolinium salts by triflic anhydride mediated intramolecular cyclisation

  摘要：

  我们发现了一种由 Tf2O 介导的分子内环化反应，并揭示了在制备中间醇过程中令人感兴趣的立体选择性和区域选择性，从而可以定制合成各种骨架取代的咪唑啉鎓盐以及结构特殊的合成-4,5-二取代咪唑啉鎓盐。

  DOI：

  10.1039/c2cc34952c
• 作为产物：
  描述：

  2,6-二异丙基苯胺 、 原甲酸三乙酯 、 邻甲苯胺 在 溶剂黄146 作用下， 反应 17.0h， 以55%的产率得到N-(2,6-diisopropylphenyl)-N'-(2-methylphenyl)formamidine
  参考文献：
  名称：

  An Efficient Synthesis of Imidazolinium Salts Using Vinyl Sulfonium Salts

  摘要：

  The synthesis of imidazolinium salts from the reaction of formamidines and (2-bromoethyl)diphenylsulfonium triflate is described. A variety of symmetrical and unsymmetrical imidazolinium Inflate salts were synthesized in high yield in short reaction times under mild conditions. Aromatic and aliphatic N-substituents work well. The reaction is proposed to proceed via generation of a vinyl sulfonium salt Intermediate frorr the bromoethylsulfonium triflate.

  DOI：

  10.1021/ol2009472

文献信息

• A facile preparation of backbone-substituted, functionalized and chiral imidazolinium salts
  作者：Jun Zhang、Xiaolong Su、Jun Fu、Min Shi

  DOI：10.1039/c1cc15609h

  日期：——

  A versatile and modular method for the preparation of various backbone-substituted, functionalized and chiral imidazolinium salts from the reaction of formamidines with alkene oxides has been described, providing a more straightforward access to substituted imidazolinium salts than the previously reported methods.

  已经描述了一种由甲modular与烯化氧反应制备各种骨架取代的，官能化的和手性的咪唑啉鎓盐的通用和模块化方法，与以前报道的方法相比，该方法提供了更直接的取代咪唑啉鎓盐的途径。
• [EN] PREPARATION OF SATURATED IMIDAZOLINIUM SALTS AND RELATED COMPOUNDS<br/>[FR] PRÉPARATION DE SELS D'IMIDAZOLINIUM SATURÉS ET COMPOSÉS ASSOCIÉS
  申请人：MATERIA INC

  公开号：WO2009062171A1

  公开（公告）日：2009-05-14

  Methods for the preparation of saturated imidazolinium salts and related compounds that comprises reaction of formamidines with compounds such as dihaioethane and an optional base are disclosed. Alternatively, the imidazoünium salts and related compounds can be prepared in a one-step process without purification of the formamidine reactant. These methods make it possible to obtain numerous imidazolinium salts and related compounds under solvent-free reaction conditions and in excellent yields.

  公开了用于制备饱和咪唑啉盐和相关化合物的方法，包括将甲酰胺与二硫乙烷等化合物发生反应以及可选的碱。另外，咪唑盐和相关化合物也可以在一步过程中制备，无需纯化甲酰胺反应物。这些方法使得在无溶剂反应条件下且产率极高的情况下获得大量咪唑啉盐和相关化合物成为可能。
• A Facile Preparation of Imidazolinium Chlorides
  作者：Kevin M. Kuhn、Robert H. Grubbs

  DOI：10.1021/ol800628a

  日期：2008.5.1

  A process for the preparation of symmetric and unsymmetric imidazolinium chlorides that involves reaction of a formamidine with dichloroethane and a base (a) is described. This method makes it possible to obtain numerous imidazolinium chlorides under solvent-free reaction conditions and in excellent yields with purification by simple filtration. Alternatively, symmetric imidazolinium chlorides can be prepared directly in moderate yields from substituted anilines by utilizing half of the formamidine intermediate as sacrificial base (b).