4-phenylbutyl (2S)-1-[(5-methoxy-1,3-benzothiazol-2-yl)sulfamoyl]piperidine-2-carboxylate | 343615-77-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-phenylbutyl (2S)-1-[(5-methoxy-1,3-benzothiazol-2-yl)sulfamoyl]piperidine-2-carboxylate
• CAS: 343615-77-0
• 化学式: C₂₄H₂₉N₃O₅S₂
• 分子量: 503.643
• InChiKey: WVBUEHXKAAMKOX-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  134
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  5-甲氧基-2-苯并噻唑胺 、 1-chlorosulfonyl-piperidine-2S-carboxylic acid 4-phenyl-butyl ester 在 3,5-二甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 以2%的产率得到4-phenylbutyl (2S)-1-[(5-methoxy-1,3-benzothiazol-2-yl)sulfamoyl]piperidine-2-carboxylate
  参考文献：
  名称：

  An efficient synthesis of sulfamides

  摘要：

  Here we report an efficient synthesis of sulfamides. 3,5-Lutidine was found to be an optimal solvent and catalyst for the reaction. The method was developed during our efforts to synthesize a series of novel FKBP-12 inhibitors in which the known ketoamide linker was replaced with sulfamide. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.106

文献信息

• An efficient synthesis of sulfamides
  作者：Chuangxing Guo、Liming Dong、Susan Kephart、Xinjun Hou

  DOI：10.1016/j.tetlet.2010.03.106

  日期：2010.5

  Here we report an efficient synthesis of sulfamides. 3,5-Lutidine was found to be an optimal solvent and catalyst for the reaction. The method was developed during our efforts to synthesize a series of novel FKBP-12 inhibitors in which the known ketoamide linker was replaced with sulfamide. (C) 2010 Elsevier Ltd. All rights reserved.