DL-leucine-(2-hydroxy-ethylamide) | 857478-31-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-leucine-(2-hydroxy-ethylamide)
• 英文别名: DL-Leucin-(2-hydroxy-aethylamid)；2-amino-N-(2-hydroxyethyl)-4-methylpentanamide
• CAS: 857478-31-0
• 化学式: C₈H₁₈N₂O₂
• 分子量: 174.243
• InChiKey: SWVVOFQOQQHCRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-benzyloxycarbonyl-DL-leucine-(2-hydroxy-ethylamide) 在 palladium on activated charcoal 、 乙醇 作用下， 生成 DL-leucine-(2-hydroxy-ethylamide)
  参考文献：
  名称：

  ÜberAminosäure-β-氧代乙酰胺。Metallionen und biologische Wirkung，35岁。

  摘要：

  Die den Depteptiden entsprechendenAminosäure-β-oxyäthyl-amide

  DOI：

  10.1002/hlca.19550380604

文献信息

• Aryl Substituted Indoles and Their Use as Blockers of Sodium Channels
  申请人：Kyle Donald J.

  公开号：US20130296281A1

  公开（公告）日：2013-11-07

  The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R 1 , and Z 1 -Z 5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及具有式（I）的芳基和杂芳基取代化合物，以及其药学上可接受的盐、前药或溶剂化物，其中G、R1和Z1-Z5如规范中所述。本发明还涉及利用式（I）的化合物治疗对钠通道阻滞有响应的疾病。本发明的化合物特别适用于治疗疼痛。
• Aryl substituted indoles and the use thereof
  申请人：Purdue Pharma L.P.

  公开号：US10202344B2

  公开（公告）日：2019-02-12

  The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R1, and Z1-Z5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及式（I）的芳基和杂芳基取代的化合物及其药学上可接受的盐、原药或溶液，其中G、R1和Z1-Z5的定义如说明书所述。本发明还涉及使用式（I）化合物治疗对阻断钠通道有反应的疾病。本发明的化合物特别适用于治疗疼痛。
• ARYL SUBSTITUTED INDOLES AND THE USE THEREOF
  申请人：Purdue Pharma L.P.

  公开号：US20160326111A1

  公开（公告）日：2016-11-10

  The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R 1 , and Z 1 -Z 5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
• US9212139B2
  申请人：——

  公开号：US9212139B2

  公开（公告）日：2015-12-15
• Über Aminosäure-β-oxyäthylamide. Metallionen und biologische Wirkung, 35. Mitteilung
  作者：D. Schäufele、B. Prijs、H. Erlenmeyer

  DOI：10.1002/hlca.19550380604

  日期：——

  Die den Dipeptiden entsprechenden Aminosäure-β-oxyäthyl-amide

  Die den Depteptiden entsprechendenAminosäure-β-oxyäthyl-amide