2-fluorobiphenyl-4,4'-diyldimethanol | 1155408-32-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-fluorobiphenyl-4,4'-diyldimethanol
• 英文别名: [4-[2-fluoro-4-(hydroxymethyl)phenyl]phenyl]methanol
• CAS: 1155408-32-4
• 化学式: C₁₄H₁₃FO₂
• 分子量: 232.254
• InChiKey: AYLHPTUCCGUARS-UHFFFAOYSA-N

物化性质

• 熔点：
  132-133 °C(Solvent: Ethanol)
• 沸点：
  401.8±45.0 °C(predicted)
• 密度：
  1.244±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-fluorobiphenyl-4,4'-diyldimethanol 在 pyridinium chlorochromate 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 20.0h， 以90%的产率得到2-fluorobiphenyl-4,4'-dicarbaldehyde
  参考文献：
  名称：

  Synthesis and properties of luminophores derived from fluorinated biphenyls

  摘要：

  A procedure was developed for the synthesis of dimethyl 2-fluoro- and 2,2 '-difluorobiphenyl-4-4 '-dicarboxylates. The latter were converted into fluorinated 4,4 ' bis[(E)-2-(1,3-benzoxazol-2-yl)ethenyl]- and 4,4 '-bis[5-(4-octyloxyphenyl)-1,3,4-oxadiazol-2-bl]biphenyls which showed strong luminescence in the crystalline state and in solution their spectral properties were examined.

  DOI：

  10.1134/s1070428008080113
• 作为产物：
  描述：

  dimethyl 2-fluorobiphenyl-4,4'-dicarboxylate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以99%的产率得到2-fluorobiphenyl-4,4'-diyldimethanol
  参考文献：
  名称：

  Synthesis and properties of luminophores derived from fluorinated biphenyls

  摘要：

  A procedure was developed for the synthesis of dimethyl 2-fluoro- and 2,2 '-difluorobiphenyl-4-4 '-dicarboxylates. The latter were converted into fluorinated 4,4 ' bis[(E)-2-(1,3-benzoxazol-2-yl)ethenyl]- and 4,4 '-bis[5-(4-octyloxyphenyl)-1,3,4-oxadiazol-2-bl]biphenyls which showed strong luminescence in the crystalline state and in solution their spectral properties were examined.

  DOI：

  10.1134/s1070428008080113

文献信息

• Synthesis, antimicrobial and antifungal activity of double quaternary ammonium salts of biphenyls
  作者：V. K. Ol’khovik、Yu. V. Matveienko、D. A. Vasilevskii、G. V. Kalechits、R. A. Zheldakova

  DOI：10.1134/s1070363213020163

  日期：2013.2

  4′-bis(chloromethyl)biphenyls were developed. Quaternization of them with various amines resulted in a series of new double quaternary ammonium salts containing the biphenyl moiety. The majority of the obtained compounds have a pronounced antifungal and antibacterial activity against the Gram-positive bacteria.

  开发了新的2-，2,2'-和3-取代的4,4'-双（氯甲基）联苯的合成方法。用各种胺对它们进行季铵化反应，产生了一系列新的含有联苯部分的双季铵盐。获得的大多数化合物对革兰氏阳性菌具有明显的抗真菌和抗菌活性。