2-(2-bromo-4-methoxyphenyl)-2,3-dihydro-3-hydroxy-3-(hydroxymethyl)-6-methoxybenzofuran-4-yl 4-methylbenzenesulfonate | 1312466-13-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-bromo-4-methoxyphenyl)-2,3-dihydro-3-hydroxy-3-(hydroxymethyl)-6-methoxybenzofuran-4-yl 4-methylbenzenesulfonate
• CAS: 1312466-13-9
• 化学式: C₂₄H₂₃BrO₈S
• 分子量: 551.412
• InChiKey: WZONOSSMPIULQP-BJKOFHAPSA-N

反应信息

• 作为产物：
  描述：

  3-(ethoxycarbonyl)-2-(2-bromo-4-methoxyphenyl)-2,3-dihydro-3-hydroxy-6-methoxybenzofuran-4-yl 4-methylbenzenesulfonate 在 锂硼氢 作用下， 以 四氢呋喃 为溶剂， 生成 2-(2-bromo-4-methoxyphenyl)-2,3-dihydro-3-hydroxy-3-(hydroxymethyl)-6-methoxybenzofuran-4-yl 4-methylbenzenesulfonate 、 2-(2-bromo-4-methoxyphenyl)-2,3-dihydro-3-hydroxy-3-(hydroxymethyl)-6-methoxybenzofuran-4-yl 4-methylbenzenesulfonate
  参考文献：
  名称：

  Asymmetric Total Syntheses of (−)-Variabilin and (−)-Glycinol

  摘要：

  Total syntheses of (-)-variabilin and (-)-glycinol have been accomplished, using the catalytic, asymmetric "Interrupted" Feist-Benary reaction (IFB) as the key transformation to introduce both stereogenic centers. A monoquinidine pyrimidinyl ether catalyst affords the IFB products In over 90% ee in both cases. Other key steps include an intramolecular Buohwald-Hartwig coupling and a nickel-catalyzed aryl tosylate reduction.

  DOI：

  10.1021/ol201332u