(R)-1-(2-cyclopentyl-acetyl)-piperidine-2-carboxylic acid (5-benzyl-4-phenyl-thiazol-2-yl)-amide | 1205598-57-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-1-(2-cyclopentyl-acetyl)-piperidine-2-carboxylic acid (5-benzyl-4-phenyl-thiazol-2-yl)-amide
• 英文别名: (2R)-N-(5-benzyl-4-phenyl-1,3-thiazol-2-yl)-1-(2-cyclopentylacetyl)piperidine-2-carboxamide
• CAS: 1205598-57-7
• 化学式: C₂₉H₃₃N₃O₂S
• 分子量: 487.666
• InChiKey: JRJUZERNBVFVCO-XMMPIXPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  90.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CYCLIC AMINE DERIVATIVE AND MEDICAL USE THEREOF
  申请人：Toray Industries, Inc.

  公开号：US20180370916A1

  公开（公告）日：2018-12-27

  A compound has retinoid-related orphan receptor γ antagonist activity and shows a therapeutic effect or a preventive effect on autoimmune diseases such as multiple sclerosis or psoriasis or allergic diseases, including allergic dermatitis or the like, such as contact dermatitis or atopic dermatitis. The cyclic amine derivative is represented by the formula or a pharmacologically acceptable salt thereof.

  一种化合物具有类视黄醇相关孤儿受体γ拮抗活性，并对自身免疫性疾病如多发性硬化或牛皮癣或过敏性疾病，包括过敏性皮炎等，如接触性皮炎或特应性皮炎等，显示治疗效果或预防效果。该环胺衍生物由以下公式或其药理学可接受的盐表示。
• Heteroaryl derivatives as DGAT1 inhibitors
  申请人：Novartis AG

  公开号：EP2380631A1

  公开（公告）日：2011-10-26

  The invention relates to compounds of formula (I): where A is a substituted thiazole or oxazole, useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

  本发明涉及式 (I) 化合物： 其中A为取代的噻唑或噁唑，可用于治疗由酰基辅酶A-二酰甘油酰基转移酶1（DGAT1）介导的疾病，如代谢紊乱。本发明还提供了治疗这类疾病的方法，以及治疗这类疾病的化合物和组合物等。
• Cyclic amine derivative and medical use thereof
  申请人：Toray Industries, Inc.

  公开号：US10364222B2

  公开（公告）日：2019-07-30

  A compound has retinoid-related orphan receptor γ antagonist activity and shows a therapeutic effect or a preventive effect on autoimmune diseases such as multiple sclerosis or psoriasis or allergic diseases, including allergic dermatitis or the like, such as contact dermatitis or atopic dermatitis. The cyclic amine derivative is represented by the formula or a pharmacologically acceptable salt thereof.

  一种化合物具有维甲酸相关孤儿受体γ拮抗剂活性，对自身免疫性疾病，如多发性硬化症或牛皮癣，或过敏性疾病，包括过敏性皮炎或类似疾病，如接触性皮炎或特应性皮炎，具有治疗或预防作用。环胺衍生物由式或其药理学上可接受的盐表示。
• Therapeutic agent or preventive agent for alopecia areata
  申请人：Toray Industries, Inc.

  公开号：US10881649B2

  公开（公告）日：2021-01-05

  A therapeutic agent or a preventive agent for alopecia areata has an RORγ antagonistic activity, and, there is a therapeutic agent or a preventive agent for alopecia areata, including a cyclic amine derivative typified by the following compound or a pharmacologically acceptable salt thereof as an active ingredient.

  脱发症的治疗剂或预防剂具有 RORγ 拮抗活性，有一种脱发症的治疗剂或预防剂，其活性成分包括以下述化合物或其药理学上可接受的盐为典型代表的环胺衍生物。
• CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
  申请人：Toray Industries, Inc.

  公开号：EP3409660B1

  公开（公告）日：2020-07-01