6-chloroacetyl-7,8-dihydroxy-coumarin | 876475-67-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 6-chloroacetyl-7,8-dihydroxy-coumarin
• 英文别名: 6-Chloracetyl-7,8-dihydroxy-cumarin
• CAS: 876475-67-1
• 化学式: C₁₁H₇ClO₅
• 分子量: 254.627
• InChiKey: BBSFANYUMYBSPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.63
• 重原子数：
  17.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  87.74
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  6-chloroacetyl-7,8-dihydroxy-coumarin 在 碳酸氢钠 作用下， 生成 3-hydroxy-9-methoxy-furo[3,2-g]chromen-7-one
  参考文献：
  名称：

  An exception to the rule: Ectopic ACTH production from functional neuroendocrine tissue in an ovarian dermoid cyst

  摘要：

  Ectopic ACTH production accounts for 15% of Cushing's syndrome presentations and is characterized by the presence of an excess of ACTH precursors. However in the case presented here ectopic ACTH production was from functional pituitary tissue within an ovarian dermoid cyst. Endocrine investigations showed that the problem behaved more like pituitary-dependent Cushing's disease and this is discussed. Furthermore, this case is one of familial dermoid cysts, another unusual phenomenon. (C) 2001, Editrice Kurtis.

  DOI：

  10.1007/bf03343930
• 作为产物：
  描述：

  邻苯三酚 在 盐酸 、 乙醚 、 硫酸 、 zinc(II) chloride 作用下， 生成 6-chloroacetyl-7,8-dihydroxy-coumarin
  参考文献：
  名称：

  An exception to the rule: Ectopic ACTH production from functional neuroendocrine tissue in an ovarian dermoid cyst

  摘要：

  Ectopic ACTH production accounts for 15% of Cushing's syndrome presentations and is characterized by the presence of an excess of ACTH precursors. However in the case presented here ectopic ACTH production was from functional pituitary tissue within an ovarian dermoid cyst. Endocrine investigations showed that the problem behaved more like pituitary-dependent Cushing's disease and this is discussed. Furthermore, this case is one of familial dermoid cysts, another unusual phenomenon. (C) 2001, Editrice Kurtis.

  DOI：

  10.1007/bf03343930