3-tert-butyl-3,5-dihydro-imidazol-4-one | 55474-51-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-tert-butyl-3,5-dihydro-imidazol-4-one
• 英文别名: 1-tert-butyl-4H-imidazol-5-one
• CAS: 55474-51-6
• 化学式: C₇H₁₂N₂O
• 分子量: 140.185
• InChiKey: WKSFRYBAPGUEOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HETEROARYL CARBONITRILES FOR THE TREATMENT OF DISEASE
  申请人：FROST Phillip

  公开号：US20180153872A1

  公开（公告）日：2018-06-07

  The invention relates to pharmaceutical compositions and dosage forms having a piperidine carbonitrile as an active ingredient for the treatment of various diseases and conditions. The preferred compound is a crystalline form of a trifluoromethylphenylalkoxyalkylheteroarylaryl piperidine carbonitrile. Methods of treating diseases and conditions are disclosed as well as processes to make crystalline forms of the above compounds.