8-(2,6-difluorobenzyl)-6-(2-fluoro-3-methoxy-phenyl)-2,2,7-trimethyl-3-(4-methylpiperazin-1-ylmethyl)-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one | 1313419-26-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 8-(2,6-difluorobenzyl)-6-(2-fluoro-3-methoxy-phenyl)-2,2,7-trimethyl-3-(4-methylpiperazin-1-ylmethyl)-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one
• 英文别名: 8-[(2,6-difluorophenyl)methyl]-6-(2-fluoro-3-methoxyphenyl)-2,2,7-trimethyl-3-[(4-methylpiperazin-1-yl)methyl]-3H-[1,3]thiazolo[3,2-a]pyridin-5-one
• CAS: 1313419-26-9
• 化学式: C₃₀H₃₄F₃N₃O₂S
• 分子量: 557.68
• InChiKey: NJSQFNDCKCXIRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  61.3
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] PYRIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] DÉRIVÉS DE PYRIDINONE ET COMPOSITIONS PHARMACEUTIQUES ASSOCIÉES
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2011076687A1

  公开（公告）日：2011-06-30

  Pyridinone derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related conditions in both men and women, as well as a mammal in general (also referred to herein as a "subject"). For example, such conditions include endometriosis, uterine fibroids, polycystic ovarian disease, heavy menstrual bleeding, particularly menorrahagia and dysmenorrehea, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reproductive therapy such as in vitro fertilization). The present application relates in particular to pyridinone derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

  吡啶酮衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制造用于治疗和/或预防疾病的药物的用途，特别是用于男性和女性的性激素相关疾病，以及一般哺乳动物（在本文中也称为“受试者”）。例如，这些疾病包括子宫内膜异位症、子宫肌瘤、多囊卵巢综合征、月经过多出血，尤其是月经过多和月经痛、多毛症、早熟、依赖性生殖腺类固醇的肿瘤，如前列腺、乳腺和卵巢癌、性腺激素释放激素依赖性垂体腺瘤、睡眠呼吸暂停、肠易激综合征、经前综合征、良性前列腺增生、避孕和不孕（例如，辅助生殖疗法，如体外受精）。本申请特别涉及吡啶酮衍生物作为促性腺激素释放激素（GnRH）受体拮抗剂。