[2-(2,5-Dioxo-pyrrolidin-1-yloxycarbonylmethylsulfanyl)-ethylsulfanyl]-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester | 769193-58-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: [2-(2,5-Dioxo-pyrrolidin-1-yloxycarbonylmethylsulfanyl)-ethylsulfanyl]-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS: 769193-58-0
• 化学式: C₁₄H₁₆N₂O₈S₂
• 分子量: 404.422
• InChiKey: UIUUDFMPSRDRPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.33
• 重原子数：
  26.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  127.36
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  1,2-十四酰基磷脂酰乙醇胺 、 [2-(2,5-Dioxo-pyrrolidin-1-yloxycarbonylmethylsulfanyl)-ethylsulfanyl]-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester 在 三乙胺 作用下， 以 氯仿 为溶剂， 以50%的产率得到
  参考文献：
  名称：

  Transbilayer Complementarity of Phospholipids. A Look beyond the Fluid Mosaic Model

  摘要：

  Lipid-lipid interactions across a phospholipid bilayer were probed by measuring the nearest-neighbor preferences of exchangeable phospholipid monomers derived from 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) in the presence of nonexchangeable DMPE- or DSPE-based dimers. Each of these permanent dimers promoted homophospholipid association to the same extent, whereas the corresponding nonexchangeable monomers were without effect. These results support a model in which the longer phospholipids in one monolayer leaflet preferentially associate with shorter ones in the adjoining monolayer. Such transbilayer complementarity is likely to play an important role in stabilizing biological membranes and also in promoting a compositional interdependence of their two lipid leaflets.

  DOI：

  10.1021/ja046892a
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 1,2-双(羧甲硫基)-乙烷 在 N,N'-二环己基碳二亚胺 作用下， 以 氯仿 为溶剂， 以50%的产率得到[2-(2,5-Dioxo-pyrrolidin-1-yloxycarbonylmethylsulfanyl)-ethylsulfanyl]-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester
  参考文献：
  名称：

  Transbilayer Complementarity of Phospholipids. A Look beyond the Fluid Mosaic Model

  摘要：

  Lipid-lipid interactions across a phospholipid bilayer were probed by measuring the nearest-neighbor preferences of exchangeable phospholipid monomers derived from 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) in the presence of nonexchangeable DMPE- or DSPE-based dimers. Each of these permanent dimers promoted homophospholipid association to the same extent, whereas the corresponding nonexchangeable monomers were without effect. These results support a model in which the longer phospholipids in one monolayer leaflet preferentially associate with shorter ones in the adjoining monolayer. Such transbilayer complementarity is likely to play an important role in stabilizing biological membranes and also in promoting a compositional interdependence of their two lipid leaflets.

  DOI：

  10.1021/ja046892a