5-acetyl-6-hydroxy-2-methyl-nicotinic acid ethyl ester | 59503-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-acetyl-6-hydroxy-2-methyl-nicotinic acid ethyl ester
• 英文别名: 5-Acetyl-6-hydroxy-2-methyl-nicotinsaeure-aethylester；Ethyl 5-acetyl-6-hydroxy-2-methylnicotinate；ethyl 5-acetyl-2-methyl-6-oxo-1H-pyridine-3-carboxylate
• CAS: 59503-67-2
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.229
• InChiKey: NEDITDTWYGVXPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-acetyl-6-hydroxy-2-methyl-nicotinic acid ethyl ester 在 5,5-二溴巴比妥酸 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 5-(2-bromo-acetyl)-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Pyrid-2-one derivatives and methods of use

  摘要：

  所选化合物对于治疗疾病，如细胞增殖或凋亡介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药学上可接受的衍生物，以及用于预防和治疗涉及中风、癌症等疾病和其他疾病或病况的药物组合物和方法。该主题发明还涉及制备此类化合物的方法，以及在这些过程中有用的中间体。

  公开号：

  US20040147561A1
• 作为产物：
  描述：

  乙酰乙酰胺 、 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 在 sodium hydride 、 盐酸 作用下， 以 四氢呋喃 、 mineral oil 、 水 为溶剂， 反应 0.5h， 生成 5-acetyl-6-hydroxy-2-methyl-nicotinic acid ethyl ester
  参考文献：
  名称：

  Pyrid-2-one derivatives and methods of use

  摘要：

  所选化合物对于治疗疾病，如细胞增殖或凋亡介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药学上可接受的衍生物，以及用于预防和治疗涉及中风、癌症等疾病和其他疾病或病况的药物组合物和方法。该主题发明还涉及制备此类化合物的方法，以及在这些过程中有用的中间体。

  公开号：

  US20040147561A1

文献信息

• Pyridine Analogues
  申请人：Andersen Soren

  公开号：US20080312208A1

  公开（公告）日：2008-12-18

  The present invention relates to certain new pyridin analogues of Formula (I) Chemical formula should be inserted here. Please see paper copy Formula (I) to processes for preparing such compounds, to their utility as P2Y 12 inhibitors and as anti-thrombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

  本发明涉及某些新的Formula (I)式吡啶类似物，化学式应在此处插入。请参见纸质副本Formula (I)，以及制备这些化合物的过程，它们作为P2Y12抑制剂和抗血栓剂等的效用，它们在心血管疾病中作为药物的用途以及含有它们的制药组合物。
• Paste, display member, and process for production of display member
  申请人：——

  公开号：US20020008470A1

  公开（公告）日：2002-01-24

  A display member, particularly a plasma display member, can be produced by a process comprising applying a paste which comprises a urethane compound and inorganic fine particles onto a substrate and then firing the paste. The display member has a post-firing pattern without any defect.

  一种显示器件，特别是等离子显示器件，可通过以下工艺生产：在基板上涂抹由聚氨酯化合物和无机微粒组成的浆料，然后烧制浆料。烧制后的显示部件具有无任何缺陷的图案。
• WO2007/8140
  申请人：——

  公开号：——

  公开（公告）日：——
• Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors
  作者：Matthew R. Kaller、Wenge Zhong、Charles Henley、Ella Magal、Thomas Nguyen、David Powers、Robert M. Rzasa、Weiya Wang、Xiaoling Xiong、Mark H. Norman

  DOI：10.1016/j.bmcl.2009.10.027

  日期：2009.12

  Cyclin-dependent kinase 5 (CDK5) is a serine-threonine protein kinase that plays a significant role in neuronal development. In association with p25, CDK5 abnormally phosphorylates a number of cellular targets involved in neurodegenerative disorders. Using active site homology and previous structure-activity relationships, a new series of potent CDK5 inhibitors was designed. This report describes the optimization of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors. (C) 2009 Elsevier Ltd. All rights reserved.
• Synthesis and cardiotonic activity of esters of 2-substituted 5-acetyl-1,6-dihydro-6-oxo-3-pyridinecarboxylic acids
  作者：L Mosti、P Schenone、M Iester、P Dorigo、RM Gaion、D Fraccarollo

  DOI：10.1016/0223-5234(93)90037-f

  日期：1993.1

  The synthesis of ethyl or methyl esters of 2-substituted 5-acetyl-1,6-dihydro-6-oxo-3-pyridinecarboxylic acids 2a-d, f and 5 by reaction of sodium acetoacetamide with ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates and ethyl 2-ethoxymethylene-4,4,4-trifluoro-3-oxobutanoate, respectively, has been described. These esters routinely gave the corresponding carboxylic acids by alkaline hydrolysis followed by acidification. As milrinone analogues, the above compounds were tested on contractile activity and frequency rate of spontaneously beating atria and on contractile activity of electrically-driven left atrium from reserpine-treated guinea pigs. Among the tested compounds, ethyl 5-acetyl-1,6-dihydro-6-oxo-2-phenyl-3-pyridinecarboxylate was found to be more potent and more effective than milrinone as a positive inotropic agent, while only marginally affecting the frequency rate.