3-(3-phenyl-1H-indol-2-yl)pyridin-2(1H)-one | 1246634-91-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-(3-phenyl-1H-indol-2-yl)pyridin-2(1H)-one
• 英文别名: 3-(3-phenyl-1H-indol-2-yl)-1H-pyridin-2-one
• CAS: 1246634-91-2
• 化学式: C₁₉H₁₄N₂O
• 分子量: 286.333
• InChiKey: GPMUHNGSFQKTCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.9
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS
  申请人：Namdev Nivedita

  公开号：US20100249127A1

  公开（公告）日：2010-09-30

  The present invention relates to substituted indolo-pyridinone compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted indolo-pyridinone compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

  本发明涉及替代的吲哚吡啶酮化合物及其合成方法。本发明还涉及含有替代吲哚吡啶酮化合物的药物组合物，以及通过向需要的对象施用这些化合物或药物组合物来治疗细胞增殖紊乱疾病，如癌症的方法。
• US8410144B2
  申请人：——

  公开号：US8410144B2

  公开（公告）日：2013-04-02
• [EN] SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS<br/>[FR] COMPOSÉS INDOLO-PYRIDINONE SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2010114896A1

  公开（公告）日：2010-10-07

  The present invention relates to substituted indolo-pyridinone compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted indolo-pyridinone compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.