5-cyclopropylidene-7-(difluoromethyl)-N-(2,3-dihydro-1H-inden-5-yl)-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide | 1380716-18-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 5-cyclopropylidene-7-(difluoromethyl)-N-(2,3-dihydro-1H-inden-5-yl)-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamide
• 英文别名: 5-cyclopropylidene-7-(difluoromethyl)-N-(2,3-dihydro-1H-inden-5-yl)-4H-pyrazolo[1,5-a]pyrimidine-3-carboxamide
• CAS: 1380716-18-6
• 化学式: C₂₀H₁₈F₂N₄O
• 分子量: 368.386
• InChiKey: BLWPNCPHSRWMOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  59
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SUBSTITUTED PYRAZOLOPYRIMIDINES AS GLUCOCEREBROSIDASE ACTIVATORS
  申请人：Marugan Juan Jose

  公开号：US20140249145A1

  公开（公告）日：2014-09-04

  Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I) in which variables R 1 -R 7 and X are described in the application.

  本文描述了替代的吡唑并嘧啶和二氢吡唑并嘧啶及相关化合物，它们的制造方法，含有这些化合物的组合物，以及在治疗溶酶体贮积病如高氏病等方面使用这些化合物的方法。这些化合物的一般式（I）中的变量R1-R7和X在本申请中描述。
• Substituted pyrazolopyrimidines as glucocerebrosidase activators
  申请人：The United States of America, as Represented by the Secretary, Department of Health and Human Service

  公开号：US10925874B2

  公开（公告）日：2021-02-23

  Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I) in which variables R1-R7 and X are described in the application.

  本文描述了取代的吡唑并嘧啶和二氢吡唑并嘧啶及相关化合物、它们的制造方法、含有这些化合物的组合物以及使用这些化合物治疗溶酶体贮积症（如戈谢病）的方法。这些化合物的通式为 (I) 其中变量 R1-R7 和 X 已在申请中说明。
• US9353117B2
  申请人：——

  公开号：US9353117B2

  公开（公告）日：2016-05-31
• US9974789B2
  申请人：——

  公开号：US9974789B2

  公开（公告）日：2018-05-22